[HTML][HTML] DNA tetrahedral nanostructures for the biomedical application and spatial orientation of biomolecules

W Wang, M Lin, W Wang, Z Shen, ZS Wu - Bioactive Materials, 2024 - Elsevier
DNA not only plays a vital role in nature as fundamental hereditary material for storing
genetic material, but also serves as well-defined functional material, for example, building …

Cellular and extracellular components in tumor microenvironment and their application in early diagnosis of cancers

R Wei, S Liu, S Zhang, L Min… - Analytical Cellular …, 2020 - Wiley Online Library
Tumors are surrounded by complex environmental components, including blood and lymph
vessels, fibroblasts, endothelial cells, immune cells, cytokines, extracellular vesicles, and …

Sensitive detection of multiple blood biomarkers via immunomagnetic exosomal PCR for the diagnosis of Alzheimer's disease

S Hu, L Zhang, Y Su, X Liang, J Yang, Q Luo… - Science …, 2024 - science.org
Blood exosomes are emerging as potential biomarkers for diagnosing brain diseases such
as Alzheimer's disease (AD). There is currently a lack of an ultrasensitive technology for …

Construction of Smart DNA‐Based Drug Delivery Systems for Cancer Therapy

C Li, M Wang, PF Li, J Sheng, Q Fu - Small, 2024 - Wiley Online Library
Due to the disadvantages of poor targeting, slow action, and low effectiveness of current
commonly used cancer treatments, including surgery, chemotherapy, and radiotherapy …

Tetrahedral DNA frameworks for biosensing and imaging analysis in living cells

Z Qi, C Wei, F Zhang, Z Wang, X Zuo - Nano Today, 2024 - Elsevier
DNA is the primary genetic material that is highly compatible with biological system, and its
intrinsic property of complementary base pairing can be programmed for analysis. However …

[HTML][HTML] Advancing breast cancer heterogeneity analysis: Insights from genomics, transcriptomics and proteomics at bulk and single-cell levels

Z Zhu, L Jiang, X Ding - Cancers, 2023 - mdpi.com
Simple Summary This review discusses the heterogeneity of breast cancer and strategies to
understand it using multi-omics profiling methods at the traditional bulk and single-cell …

Nucleic acids analysis

Y Zhao, X Zuo, Q Li, F Chen, YR Chen, J Deng… - Science China …, 2021 - Springer
Nucleic acids are natural biopolymers of nucleotides that store, encode, transmit and
express genetic information, which play central roles in diverse cellular events and diseases …

A hydrogel-based mechanical metamaterial for the interferometric profiling of extracellular vesicles in patient samples

H Zhao, S Pan, A Natalia, X Wu, CAJ Ong… - Nature Biomedical …, 2023 - nature.com
The utility of mechanical metamaterials for biomedical applications has seldom been
explored. Here we show that a metamaterial that is mechanically responsive to antibody …

Extracellular vesicle drug occupancy enables real-time monitoring of targeted cancer therapy

S Pan, Y Zhang, A Natalia, CZJ Lim, NRY Ho… - Nature …, 2021 - nature.com
Current technologies to measure drug–target interactions require complex processing and
invasive tissue biopsies, limiting their clinical utility for cancer treatment monitoring. Here we …

Intracellular entropy‐driven multi‐bit DNA computing for tumor progression discrimination

M Bai, F Chen, X Cao, Y Zhao, J Xue… - Angewandte Chemie …, 2020 - Wiley Online Library
Tumor progressions such as metastasis are complicated events that involve abnormal
expression of different miRNAs and enzymes. Monitoring these biomolecules in live cells …