Amyloid refers to insoluble protein aggregates that are responsible for amyloid diseases but
are also implicated in important physiological functions (functional amyloids). The …

Currently, one of the most significant and rapidly growing unmet medical challenges is the
treatment of neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's …

A range of human degenerative conditions, including Alzheimer's disease, light-chain
amyloidosis and the spongiform encephalopathies, is associated with the deposition in …

An experimental determination of the thermodynamic stabilities of a series of amyloid fibrils
reveals that this structural form is likely to be the most stable one that protein molecules can …

The presence of β‐sheets in the core of amyloid fibrils raised questions as to whether or not
β‐sheet‐containing proteins, such as transthyretin, are predisposed to form such fibrils …

Oligomeric intermediates are non-fibrillar polypeptide assemblies that occur during amyloid
fibril formation and that are thought to underlie the aetiology of amyloid diseases, such as …

Dopa (3, 4-dihydroxyphenylalanine) is recognized as a key chemical signature of mussel
adhesion and has been adopted into diverse synthetic polymer systems. Dopa's notorious …

We study the effect of pH and temperature on fibril formation from hen egg white lysozyme.
Fibril formation is promoted by low pH and temperatures close to the midpoint temperature …

Extracellular matrices (ECM) play an enormous role in any living system, controlling various
factors and eventually fates of cells. ECM regulates cell fate by providing constant …

Amyloid fibrils are thread-like protein aggregates with a core region formed from repetitive
arrays of β-sheets oriented parallel to the fibril axis,. Such structures were first recognized in …