Abnormal signaling at corticotropin-releasing factor CRF 1 and CRF 2 receptors might
contribute to the pathophysiology of stress-related disorders such as anxiety, depression …

The vertebrate hypothalamus–pituitary–adrenal (HPA; or interrenal) axis plays pivotal roles
in animal development and in physiological and behavioral adaptation to environmental …

Corticotropin releasing factor (CRF) is a major integrator of adaptive responses to stress.
Two biochemically and pharmacologically distinct CRF receptor subtypes (CRFR1 and …

Receptors for corticotropin-releasing factor (CRF) are members of a family of G protein-
coupled receptors (“Family B”) that respond to a variety of structurally dissimilar releasing …

Two different corticotropin‐releasing factor (CRF) receptors, CRF1 and CRF2, have been
identified in rat and human brain. Although the two receptor subtypes show a markedly …

Corticotropin-releasing factor (CRF), urotensin-I, urocortin and sauvagine belong to a family
of related neuropeptides found throughout chordate taxa and likely stem from an ancestral …

Corticotropin-releasing hormone (CRH) has been implicated in the regulation of a wide
range of behaviors including arousal, motor function, feeding, and reproduction. Because …

Publisher Summary Amphibians exhibit considerable diversity in behavioral, physiological,
and life history strategies. They are geographically widespread, occupying a diverse range …

The environment experienced by develo** organisms can shape the timing and character
of developmental processes, generating different phenotypes from the same genotype, each …

Major depressive disorder (MDD) increases the risk of type 2 diabetes (T2D) by 60% in
untreated patients, and hypercortisolism is common in MDD as well as in some patients with …