Imaging and biophysical modelling of thrombogenic mechanisms in atrial fibrillation and stroke

A Qureshi, GYH Lip, DA Nordsletten… - Frontiers in …, 2023 - frontiersin.org
Atrial fibrillation (AF) underlies almost one third of all ischaemic strokes, with the left atrial
appendage (LAA) identified as the primary thromboembolic source. Current stroke risk …

A review of quantitative systems pharmacology models of the coagulation Cascade: opportunities for improved usability

D Chung, S Bakshi, PH van der Graaf - Pharmaceutics, 2023 - mdpi.com
Despite the numerous therapeutic options to treat bleeding or thrombosis, a comprehensive
quantitative mechanistic understanding of the effects of these and potential novel therapies …

Modelling and simulations of the SEIR and Blood Coagulation systems using Atangana-Baleanu-Caputo derivative

M Partohaghighi, A Akgül - Chaos, Solitons & Fractals, 2021 - Elsevier
In this work, we investigate the SEIR and Blood Coagulation systems using a specific type of
fractional derivative. SEIR epidemic model which outlines the close communication of …

Novel mathematical modelling of platelet-poor plasma arising in a blood coagulation system with the fractional Caputo–Fabrizio derivative

M Partohaghighi, A Akgül, L Guran, MF Bota - Symmetry, 2022 - mdpi.com
This study develops a fractional model using the Caputo–Fabrizio derivative with order α for
platelet-poor plasma arising in a blood coagulation system. The existence of solutions …

[HTML][HTML] Influence of vortical structures on fibrin clot formation in cerebral aneurysms: A two-dimensional computational study

T Ngwenya, D Grundlingh, MN Ngoepe - Journal of Biomechanics, 2024 - Elsevier
Thrombosis is an important contributor to cerebral aneurysm growth and progression. A
number of sophisticated multiscale and multiphase in silico models have been developed …

Combining mathematical modeling and deep learning to make rapid and explainable predictions of the patient-specific response to anticoagulant therapy under …

A Bouchnita, P Nony, JP Llored, V Volpert - Mathematical Biosciences, 2022 - Elsevier
Anticoagulant drugs are commonly prescribed to prevent hypercoagulable states in patients
with venous thromboembolism. The choice of the most efficient anticoagulant and the …

A mathematical model of blood loss during renal resection

J Cowley, X Luo, GD Stewart, W Shu, A Kazakidi - Fluids, 2023 - mdpi.com
In 2021, approximately 51% of patients diagnosed with kidney tumors underwent surgical
resections. One possible way to reduce complications from surgery is to minimise the …

Thrombin Generation Thresholds for Coagulation Initiation under Flow

A Bouchnita, K Yadav, JP Llored, A Gurovich, V Volpert - Axioms, 2023 - mdpi.com
In veins, clotting initiation displays a threshold response to flow intensity and injury size.
Mathematical models can provide insights into the conditions leading to clot growth initiation …

Hemodynamics Affects Factor XI/XII Anticoagulation Efficacy in Patient-Specific Left Atrial Models

M Guerrero-Hurtado, M Garcia-Villalba, A Gonzalo… - bioRxiv, 2024 - biorxiv.org
Atrial fibrillation (AF) disrupts the circulation of blood through the left atrium (LA), and may
result in relative stasis in the left atrial appendage (LAA), increasing thromboembolic risk …

A novel interferometry-based optical sensor to study the coagulation of human plasma

A Das, KR Nair, H Ashok, T Subeesh… - Optics & Laser …, 2025 - Elsevier
We propose and demonstrate a Twin-interferometry (TIM) based optical approach for
studying and exploring anisotropy and directional dependent coagulation kinetics in human …