Harnessing non-destructive 3D pathology

JTC Liu, AK Glaser, K Bera, LD True… - Nature biomedical …, 2021‏ - nature.com
High-throughput methods for slide-free three-dimensional (3D) pathological analyses of
whole biopsies and surgical specimens offer the promise of modernizing traditional …

Measurement of tissue optical properties in a wide spectral range: a review

IS Martins, HF Silva, EN Lazareva… - Biomedical Optics …, 2022‏ - opg.optica.org
A distinctive feature of this review is a critical analysis of methods and results of
measurements of the optical properties of tissues in a wide spectral range from deep UV to …

Digital synthesis of histological stains using micro-structured and multiplexed virtual staining of label-free tissue

Y Zhang, K de Haan, Y Rivenson, J Li, A Delis… - Light: Science & …, 2020‏ - nature.com
Histological staining is a vital step in diagnosing various diseases and has been used for
more than a century to provide contrast in tissue sections, rendering the tissue constituents …

[HTML][HTML] Emerging advances to transform histopathology using virtual staining

WW Dean - BME frontiers, 2020‏ - spj.science.org
In an age where digitization is widespread in clinical and preclinical workflows, pathology is
still predominantly practiced by microscopic evaluation of stained tissue specimens affixed …

Deep learning-enabled realistic virtual histology with ultraviolet photoacoustic remote sensing microscopy

MT Martell, NJM Haven, BD Cikaluk, BS Restall… - Nature …, 2023‏ - nature.com
The goal of oncologic surgeries is complete tumor resection, yet positive margins are
frequently found postoperatively using gold standard H&E-stained histology methods …

[HTML][HTML] Contemporary whole slide imaging devices and their applications within the modern pathology department: a selected hardware review

A Patel, UGJ Balis, J Cheng, Z Li, G Lujan… - Journal of Pathology …, 2021‏ - Elsevier
Digital pathology (DP) has disrupted the practice of traditional pathology, including
applications in education, research, and clinical practice. Contemporary whole slide imaging …

Pocket MUSE: an affordable, versatile and high-performance fluorescence microscope using a smartphone

Y Liu, AM Rollins, RM Levenson, F Fereidouni… - Communications …, 2021‏ - nature.com
Smartphone microscopes can be useful tools for a broad range of imaging applications. This
manuscript demonstrates the first practical implementation of Microscopy with Ultraviolet …

Rapid pathology of lumpectomy margins with open-top light-sheet (OTLS) microscopy

Y Chen, W **e, AK Glaser, NP Reder, C Mao… - Biomedical optics …, 2019‏ - opg.optica.org
Open-top light-sheet microscopy is a technique that can potentially enable rapid ex vivo
inspection of large tissue surfaces and volumes. Here, we have optimized an open-top light …

Deep-learning-assisted microscopy with ultraviolet surface excitation for rapid slide-free histological imaging

Z Chen, W Yu, IHM Wong, TTW Wong - Biomedical Optics Express, 2021‏ - opg.optica.org
Histopathological examination of tissue sections is the gold standard for disease diagnosis.
However, the conventional histopathology workflow requires lengthy and laborious sample …

FalseColor-Python: a rapid intensity-leveling and digital-staining package for fluorescence-based slide-free digital pathology

R Serafin, W **e, AK Glaser, JTC Liu - Plos one, 2020‏ - journals.plos.org
Slide-free digital pathology techniques, including nondestructive 3D microscopy, are gaining
interest as alternatives to traditional slide-based histology. In order to facilitate clinical …