PROTAC targeted protein degraders: the past is prologue

M Békés, DR Langley, CM Crews - Nature reviews Drug discovery, 2022 - nature.com
Targeted protein degradation (TPD) is an emerging therapeutic modality with the potential to
tackle disease-causing proteins that have historically been highly challenging to target with …

Accelerating antiviral drug discovery: lessons from COVID-19

A Von Delft, MD Hall, AD Kwong, LA Purcell… - Nature Reviews Drug …, 2023 - nature.com
During the coronavirus disease 2019 (COVID-19) pandemic, a wave of rapid and
collaborative drug discovery efforts took place in academia and industry, culminating in …

[HTML][HTML] Inflammasome activation in infected macrophages drives COVID-19 pathology

E Sefik, R Qu, C Junqueira, E Kaffe, H Mirza, J Zhao… - Nature, 2022 - nature.com
Severe COVID-19 is characterized by persistent lung inflammation, inflammatory cytokine
production, viral RNA and a sustained interferon (IFN) response, all of which are …

Structural biology of SARS-CoV-2: open the door for novel therapies

W Yan, Y Zheng, X Zeng, B He, W Cheng - Signal Transduction and …, 2022 - nature.com
Abstract Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the causative
agent of the pandemic disease COVID-19, which is so far without efficacious treatment. The …

Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis

F Kabinger, C Stiller, J Schmitzová… - Nature structural & …, 2021 - nature.com
Molnupiravir is an orally available antiviral drug candidate currently in phase III trials for the
treatment of patients with COVID-19. Molnupiravir increases the frequency of viral RNA …

Coronavirus biology and replication: implications for SARS-CoV-2

P V'kovski, A Kratzel, S Steiner, H Stalder… - Nature Reviews …, 2021 - nature.com
The SARS-CoV-2 pandemic and its unprecedented global societal and economic disruptive
impact has marked the third zoonotic introduction of a highly pathogenic coronavirus into the …

SARS-CoV-2: structure, biology, and structure-based therapeutics development

MY Wang, R Zhao, LJ Gao, XF Gao… - Frontiers in cellular …, 2020 - frontiersin.org
The pandemic of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
has been posing great threats to the world in many aspects. Effective therapeutic and …

COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives

M Nishiga, DW Wang, Y Han, DB Lewis… - Nature Reviews …, 2020 - nature.com
Abstract Coronavirus disease 2019 (COVID-19), caused by a strain of coronavirus known as
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global …

A systematic review of SARS-CoV-2 vaccine candidates

Y Dong, T Dai, Y Wei, L Zhang, M Zheng… - Signal transduction and …, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging virus that is
highly pathogenic and has caused the recent worldwide pandemic officially named …

SARS-CoV-2: from its discovery to genome structure, transcription, and replication

AC Brant, W Tian, V Majerciak, W Yang, ZM Zheng - Cell & bioscience, 2021 - Springer
SARS-CoV-2 is an extremely contagious respiratory virus causing adult atypical pneumonia
COVID-19 with severe acute respiratory syndrome (SARS). SARS-CoV-2 has a single …