Liddle syndrome is an inherited form of low-renin hypertension, transmitted with an
autosomal dominant pattern. The molecular basis of Liddle syndrome resides in germline …

Ubiquitin specific protease (USP) 2 is a multifunctional deubiquitinating enzyme. USP2
modulates cell cycle progression, and therefore carcinogenesis, via the deubiquitination of …

Intercalated cells (ICs) are found in the connecting tubule and the collecting duct. Of the
three IC subtypes identified, type B intercalated cells are one of the best characterized and …

Salt sensitivity is an independent CVD and mortality risk factor, which is present in both
hypertensive and normotensive populations. It is genetically determined and it may affect the …

STIM and Orai isoforms orchestrate store operated Ca2+ entry (SOCE) and thus cytosolic
Ca2+ fluctuations following stimulation by hormones, growth factors and further mediators …

The development of preeclampsia (PE) seriously affects the health of the mother and the
child, but the precise pathogenesis of PE remains elusive. The placenta is considered to …

The autonomic nervous system maintains homeostasis of cardiovascular, respiratory,
gastrointestinal, urinary, immune, and thermoregulatory function. Homeostasis involves a …

Regulation of our water homeostasis is fine-tuned by dynamic translocation of Aquaporin-2
(AQP2)-bearing vesicles to and from the plasma membrane of renal principal cells. Whereas …

Many rare kidney disorders exhibit a monogenic, Mendelian pattern of inheritance.
Population-based genetic studies have identified many genetic variants associated with an …

Blood pressure has a significant genetic component, but less than 3% of the observed
variance has been attributed to genetic variants identified to date. Candidate gene studies of …