Induced pluripotent stem cells (iPSCs): molecular mechanisms of induction and applications
The induced pluripotent stem cell (iPSC) technology has transformed in vitro research and
holds great promise to advance regenerative medicine. iPSCs have the capacity for an …
holds great promise to advance regenerative medicine. iPSCs have the capacity for an …
Human organoids in basic research and clinical applications
Organoids are three-dimensional (3D) miniature structures cultured in vitro produced from
either human pluripotent stem cells (hPSCs) or adult stem cells (AdSCs) derived from …
either human pluripotent stem cells (hPSCs) or adult stem cells (AdSCs) derived from …
Molecular landscapes of human hippocampal immature neurons across lifespan
Immature dentate granule cells (imGCs) arising from adult hippocampal neurogenesis
contribute to plasticity and unique brain functions in rodents, and are dysregulated in …
contribute to plasticity and unique brain functions in rodents, and are dysregulated in …
[HTML][HTML] Single-cell brain organoid screening identifies developmental defects in autism
The development of the human brain involves unique processes (not observed in many
other species) that can contribute to neurodevelopmental disorders,,–. Cerebral organoids …
other species) that can contribute to neurodevelopmental disorders,,–. Cerebral organoids …
Proper acquisition of cell class identity in organoids allows definition of fate specification programs of the human cerebral cortex
Realizing the full utility of brain organoids to study human development requires
understanding whether organoids precisely replicate endogenous cellular and molecular …
understanding whether organoids precisely replicate endogenous cellular and molecular …
Genetics of human brain development
Brain development in humans is achieved through precise spatiotemporal genetic control,
the mechanisms of which remain largely elusive. Recently, integration of technological …
the mechanisms of which remain largely elusive. Recently, integration of technological …
Functional neuronal circuitry and oscillatory dynamics in human brain organoids
Human brain organoids replicate much of the cellular diversity and developmental anatomy
of the human brain. However, the physiology of neuronal circuits within organoids remains …
of the human brain. However, the physiology of neuronal circuits within organoids remains …
Morphological diversification and functional maturation of human astrocytes in glia-enriched cortical organoid transplanted in mouse brain
Astrocytes, the most abundant glial cell type in the brain, are underrepresented in traditional
cortical organoid models due to the delayed onset of cortical gliogenesis. Here we introduce …
cortical organoid models due to the delayed onset of cortical gliogenesis. Here we introduce …
[HTML][HTML] Structural and functional integration of human forebrain organoids with the injured adult rat visual system
Brain organoids created from human pluripotent stem cells represent a promising approach
for brain repair. They acquire many structural features of the brain and raise the possibility of …
for brain repair. They acquire many structural features of the brain and raise the possibility of …
Human brain organogenesis: Toward a cellular understanding of development and disease
The construction of the human nervous system is a distinctly complex although highly
regulated process. Human tissue inaccessibility has impeded a molecular understanding of …
regulated process. Human tissue inaccessibility has impeded a molecular understanding of …