The need for new antibacterial drugs to treat the increasing global prevalence of drug-
resistant bacterial infections has clearly attracted global attention, with a range of existing …

The limited armamentarium against drug-resistant Gram-negative bacilli has led to the
development of several novel β-lactam–β-lactamase inhibitor combinations (BLBLIs). In this …

The problem of antibiotic resistance is on the rise, with multidrug-resistant strains emerging
even to the last resort antibiotics. The drug discovery process is often stalled by stringent cut …

The β-lactams retain a central place in the antibacterial armamentarium. In Gram-negative
bacteria, β-lactamase enzymes that hydrolyze the amide bond of the four-membered β …

The term B-factor, sometimes called the Debye–Waller factor, temperature factor, or atomic
displacement parameter, is used in protein crystallography to describe the attenuation of X …

The development of new and effective antibacterial drugs to treat multi-drug resistant (MDR)
bacteria, especially Gram-negative (G− ve) pathogens, is acknowledged as one of the …

This chapter analyzes the epidemiology of Carbapenem-Resistant Enterobacteriaceae
(CRE) as well as current and future treatment options against the increasingly resistant …

Infections of antibiotic-resistant pathogens pose an ever-increasing threat to mankind. The
investigation of novel approaches for tackling the antimicrobial resistance crisis must be part …

Carbapenem-resistant Acinetobacter baumannii (CRAB) is a perilous nosocomial pathogen
causing substantial morbidity and mortality. Current treatment options for CRAB are limited …

Microbial resistance is a serious threat to human health worldwide. Among the World Health
Organisation's list of priority resistant bacteria, three are listed as critical—the highest level of …