Dietary restriction (DR) is the most robust environmental manipulation known to increase
active and healthy lifespan in many species. Despite differences in the protocols and the …

The mechanisms underlying biological aging have been extensively studied in the past 20
years with the avail of mainly four model organisms: the budding yeast Saccharomyces …

Bacteria can form biofilms that consist of multicellular communities embedded in an
extracellular matrix (ECM). In Bacillus subtilis, the main protein component of the ECM is the …

The extracellular pH (pHe) is a key determinant of the cellular (micro) environment and
needs to be maintained within strict boundaries to allow normal cell function. Here we used …

The anti-aging activity of many plant flavonoids, as well as their mechanisms of action, have
been explored in the current literature. However, the studies on the synergistic effects …

It is established that glucose restriction extends yeast chronological and replicative lifespan,
but little is known about the influence of amino acids on yeast lifespan, although some …

Pyridine nucleotides are essential coenzymes in many cellular redox reactions in all living
systems. In addition to functioning as a redox carrier, NAD+ is also a required co-substrate …

For more than 50 years, the free radical theory served as the paradigm guiding most
investigations of ageing. However, recent studies in a variety of organisms have identified …

The concept of ageing is one that has intrigued mankind since the beginning of time and is
now more important than ever as the incidence of age-related disorders is increasing in our …

Upon starvation for glucose or any other macronutrient, yeast cells exit from the mitotic cell
cycle and acquire a set of characteristics that are specific to quiescent cells to ensure …