Wnt/β-catenin signaling components and mechanisms in bone formation, homeostasis, and disease
Wnts are secreted, lipid-modified proteins that bind to different receptors on the cell surface
to activate canonical or non-canonical Wnt signaling pathways, which control various …
to activate canonical or non-canonical Wnt signaling pathways, which control various …
[HTML][HTML] Wnt/β-catenin signaling, disease, and emerging therapeutic modalities
The WNT signal transduction cascade is a main regulator of development throughout the
animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult …
animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult …
A road map for understanding molecular and genetic determinants of osteoporosis
Osteoporosis is a highly prevalent disorder characterized by low bone mineral density and
an increased risk of fracture, termed osteoporotic fracture. Notably, bone mineral density …
an increased risk of fracture, termed osteoporotic fracture. Notably, bone mineral density …
Paracrine and endocrine actions of bone—the functions of secretory proteins from osteoblasts, osteocytes, and osteoclasts
The skeleton is a dynamic organ that is constantly remodeled. Proteins secreted from bone
cells, namely osteoblasts, osteocytes, and osteoclasts exert regulation on …
cells, namely osteoblasts, osteocytes, and osteoclasts exert regulation on …
The National Osteoporosis Foundation's position statement on peak bone mass development and lifestyle factors: a systematic review and implementation …
Abstract Lifestyle choices influence 20–40% of adult peak bone mass. Therefore,
optimization of lifestyle factors known to influence peak bone mass and strength is an …
optimization of lifestyle factors known to influence peak bone mass and strength is an …
[HTML][HTML] Mechanical basis of bone strength: influence of bone material, bone structure and muscle action
This review summarises current understanding of how bone is sculpted through adaptive
processes, designed to meet the mechanical challenges it faces in everyday life and athletic …
processes, designed to meet the mechanical challenges it faces in everyday life and athletic …
Genetic architecture: the shape of the genetic contribution to human traits and disease
Genetic architecture describes the characteristics of genetic variation that are responsible for
heritable phenotypic variability. It depends on the number of genetic variants affecting a trait …
heritable phenotypic variability. It depends on the number of genetic variants affecting a trait …
Twelve years of GWAS discoveries for osteoporosis and related traits: advances, challenges and applications
Osteoporosis is a common skeletal disease, affecting~ 200 million people around the world.
As a complex disease, osteoporosis is influenced by many factors, including diet (eg calcium …
As a complex disease, osteoporosis is influenced by many factors, including diet (eg calcium …
Genome-wide association analysis of 19,629 individuals identifies variants influencing regional brain volumes and refines their genetic co-architecture with cognitive …
Volumetric variations of the human brain are heritable and are associated with many brain-
related complex traits. Here we performed genome-wide association studies (GWAS) of 101 …
related complex traits. Here we performed genome-wide association studies (GWAS) of 101 …
Wnt pathway in bone repair and regeneration–what do we know so far
KS Houschyar, C Tapking, MR Borrelli… - Frontiers in cell and …, 2019 - frontiersin.org
Wnt signaling plays a central regulatory role across a remarkably diverse range of functions
during embryonic development, including those involved in the formation of bone and …
during embryonic development, including those involved in the formation of bone and …