Abstract Structure and function are highly correlated in the vertebrate retina, a sensory tissue
that is organized into cell layers with microcircuits working in parallel and together to encode …

Glaucoma is one of the leading causes of vision impairment worldwide. In order to further
understand the molecular pathobiology of this disease and to develop better therapies …

Intraocular pressure (IOP) elevation is a principal risk factor for glaucoma. Using a
microbead injection technique to chronically raise IOP for 15 or 30 d in mice, we identified …

Retinal ganglion cell (RGC) loss is a hallmark of glaucoma and the second leading cause of
blindness worldwide. The type and timing of cellular changes leading to RGC loss in …

Retinal ganglion cell (RGC) degeneration causes vision loss in patients with glaucoma, and
this has been generally considered to be irreversible due to RGC death. We question this …

Glaucoma is the second leading cause of blindness worldwide, affecting an estimated 70
million people (Quigley, 2011; Pascolini and Mariotti, 2012). It causes a progressive and …

Vision loss in glaucoma is caused by progressive dysfunction of retinal ganglion cells
(RGCs) and optic nerve atrophy. Here, we investigated the effectiveness of BDNF treatment …

Glaucoma, the leading cause of irreversible blindness worldwide, is characterized by the
selective death of retinal ganglion cells (RGCs). Ocular hypertension is the most significant …

Neuroprotective therapies which focus on factors leading to retinal ganglion cells (RGCs)
degeneration have been drawing more and more attention. The beneficial effects of nerve …

Background Optic nerve injury (ONI) is a key cause of irreversible blindness and triggers
retinal ganglion cells (RGCs) change and synapse loss. Microglia is the resistant immune …