Global burden of disease: acute-on-chronic liver failure, a systematic review and meta-analysis

G Mezzano, A Juanola, A Cardenas, E Mezey… - Gut, 2022 - gut.bmj.com
Background and aims Acute-on-chronic liver failure (ACLF) is characterised by acute
decompensation of cirrhosis associated with organ failures. We systematically evaluated the …

Acute-on-chronic liver failure: an update

R Hernaez, E Solà, R Moreau, P Ginès - Gut, 2017 - gut.bmj.com
Acute-on-chronic liver failure (ACLF) is a syndrome characterised by acute decompensation
of chronic liver disease associated with organ failures and high short-term mortality. Alcohol …

EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis

P Angeli, M Bernardi, C Villanueva, C Francoz… - Journal of …, 2018 - Elsevier
The natural history of cirrhosis is characterised by an asymptomatic compensated phase
followed by a decompensated phase, marked by the development of overt clinical signs, the …

Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update

SK Sarin, A Choudhury, MK Sharma, R Maiwall… - Hepatology …, 2019 - Springer
The first consensus report of the working party of the Asian Pacific Association for the Study
of the Liver (APASL) set up in 2004 on acute-on-chronic liver failure (ACLF) was published …

Coronavirus disease 2019 hangover: a rising tide of alcohol use disorder and alcohol‐associated liver disease

BL Da, GY Im, TD Schiano - Hepatology, 2020 - journals.lww.com
Abstract The coronavirus disease 2019 (COVID‐19) pandemic has had a tremendous global
impact since it began in November of 2019. However, there are concerns that the COVID‐19 …

Utilizing the gut microbiome in decompensated cirrhosis and acute-on-chronic liver failure

J Trebicka, P Bork, A Krag, M Arumugam - … reviews Gastroenterology & …, 2021 - nature.com
The human gut microbiome has emerged as a major player in human health and disease.
The liver, as the first organ to encounter microbial products that cross the gut epithelial …

Acute-on-chronic liver failure

V Arroyo, R Moreau, R Jalan - New England Journal of Medicine, 2020 - Mass Medical Soc
Acute-on-Chronic Liver Failure Acute decompensation in patients with chronic liver disease
is called acute-on-chronic liver failure. Usually, systemic inflammation from infection or an …

Development of diagnostic criteria and a prognostic score for hepatitis B virus-related acute-on-chronic liver failure

T Wu, J Li, L Shao, J **n, L Jiang, Q Zhou, D Shi… - Gut, 2018 - gut.bmj.com
Objective The definition of acute-on-chronic liver failure (ACLF) based on cirrhosis,
irrespective of aetiology, remains controversial. This study aimed to clarify the …

[HTML][HTML] Acute-on-chronic liver failure: definitions, pathophysiology and principles of treatment

G Zaccherini, E Weiss, R Moreau - JHEP Reports, 2021 - Elsevier
The term acute-on-chronic liver failure (ACLF) defines an abrupt and life-threatening
worsening of clinical conditions in patients with cirrhosis or chronic liver disease. In recent …

Acute-on-chronic liver failure in cirrhosis

V Arroyo, R Moreau, PS Kamath, R Jalan… - Nature reviews Disease …, 2016 - nature.com
The definition of acute-on-chronic liver failure (ACLF) remains contested. In Europe and
North America, the term is generally applied according to the European Association for the …