miR-221/222 as biomarkers and targets for therapeutic intervention on cancer and other diseases: A systematic review
Among deregulated microRNAs (miRs) in human malignancies, miR-221 has been widely
investigated for its oncogenic role and as a promising biomarker. Moreover, recent evidence …
investigated for its oncogenic role and as a promising biomarker. Moreover, recent evidence …
Targeted delivery of miRNA based therapeuticals in the clinical management of Glioblastoma Multiforme
Glioblastoma multiforme (GBM) is the most aggressive (WHO grade IV) form of diffuse
glioma endowed with tremendous invasive capacity. The availability of narrow therapeutic …
glioma endowed with tremendous invasive capacity. The availability of narrow therapeutic …
The role of microRNAs in multidrug resistance of glioblastoma
Simple Summary Glioblastoma (GBM) is one of the most malignant types of central nervous
system tumor which accounts for more than 60% of all brain tumors in adults. Owing to poor …
system tumor which accounts for more than 60% of all brain tumors in adults. Owing to poor …
RETRACTED ARTICLE: Human bone marrow-derived mesenchymal stem cell-secreted exosomes overexpressing microRNA-34a ameliorate glioblastoma …
Purpose Exosomes play important roles in intercellular communication through signaling
pathways affecting tumor microenvironment modulation and tumor proliferation, including …
pathways affecting tumor microenvironment modulation and tumor proliferation, including …
Dual biomarkers long non-coding RNA GAS5 and microRNA-34a co-expression signature in common solid tumors
Accumulating evidence indicates that non-coding RNAs including microRNAs (miRs) and
long non-coding RNAs (lncRNAs) are aberrantly expressed in cancer, providing promising …
long non-coding RNAs (lncRNAs) are aberrantly expressed in cancer, providing promising …
The role of miRNA for the treatment of MGMT unmethylated glioblastoma multiforme
Glioblastoma multiforme (GBM) is the most common high-grade intracranial tumor in adults.
It is characterized by uncontrolled proliferation, diffuse infiltration due to high invasive and …
It is characterized by uncontrolled proliferation, diffuse infiltration due to high invasive and …
Clinical impact of circulating oncogenic MiRNA-221 and MiRNA-222 in glioblastoma multiform
M Swellam, L Ezz El Arab, AS Al-Posttany… - Journal of Neuro …, 2019 - Springer
Background and aim Glioblastoma multiform (GBM); most fatal brain cancer, is incurable
with molecular diversity hence identification of molecular targets that contribute to GBM …
with molecular diversity hence identification of molecular targets that contribute to GBM …
Prediction of disease-associated circRNAs via circRNA–disease pair graph and weighted nuclear norm minimization
Circular RNA (circRNA) is a special single-stranded, non-coding RNA molecule. A variety of
circRNAs are widely distributed in organisms and can regulate gene expression by …
circRNAs are widely distributed in organisms and can regulate gene expression by …
Reduced EGFR and increased miR-221 is associated with increased resistance to temozolomide and radiotherapy in glioblastoma
Z Areeb, SF Stuart, AJ West, J Gomez, HPT Nguyen… - Scientific reports, 2020 - nature.com
Despite aggressive treatment with temozolomide and radiotherapy and extensive research
into alternative therapies there has been little improvement in Glioblastoma patient survival …
into alternative therapies there has been little improvement in Glioblastoma patient survival …
Vaccine-based immunotherapeutics for the treatment of glioblastoma: advances, challenges, and future perspectives
JA Cuoco, MJ Benko, CM Busch, CM Rogers… - World Neurosurgery, 2018 - Elsevier
Highlights•Despite standard of care, glioblastoma carries a dismal prognosis.•Glioblastoma
cells decrease immunogenicity while promoting gliomagenesis.•Peptides, heat-shock …
cells decrease immunogenicity while promoting gliomagenesis.•Peptides, heat-shock …