▪ Abstract Alternative pre-mRNA splicing is a central mode of genetic regulation in higher
eukaryotes. Variability in splicing patterns is a major source of protein diversity from the …

Genome-wide analyses of metazoan transcriptomes have revealed an unexpected level of
mRNA diversity that is generated by alternative splicing. Recently, regulatory networks have …

Genome-wide association studies have identified thousands of noncoding variants
associated with human traits and diseases. However, the functional interpretation of these …

Protein lysine acetylation has emerged as a key posttranslational modification in cellular
regulation, in particular through the modification of histones and nuclear transcription …

Alternative splicing of pre-mRNA is a prominent mechanism to generate protein diversity, yet
its regulation is poorly understood. We demonstrated a direct role for histone modifications …

The global shortening of messenger RNAs through alternative polyadenylation (APA) that
occurs during enhanced cellular proliferation represents an important, yet poorly understood …

In violation of the'one gene, one polypeptide'rule, alternative splicing allows individual
genes to produce multiple protein isoforms—thereby playing a central part in generating …

Alternative pre-mRNA splicing is a highly cell type–specific process essential to generating
protein diversity. However, the mechanisms responsible for the establishment and …

Eukaryotic protein-encoding genes possess poly (A) signals that define the end of the
messenger RNA and mediate downstream transcriptional termination by RNA polymerase II …

The finding that the metazoan hypoxic response is regulated by oxygen-dependent
posttranslational hydroxylations, which regulate the activity and lifetime of hypoxia-inducible …