Significant recent progress in understanding rheumatoid arthritis (RA) pathogenesis has led
to improved treatment and quality of life. The introduction of targeted-biologic and-synthetic …

Rheumatoid arthritis is a chronic autoimmune disease that causes progressive articular
damage, functional loss, and comorbidity. The development of effective biologics and small …

Cytokine-mediated pathways are central to the pathogenesis of rheumatoid arthritis (RA).
The purpose of this short Opinion article is to briefly overview the roles of cytokine families in …

Background Nonresponse and loss of response to anti‐TNF therapies in Crohn's disease
represent significant clinical problems for which clear management guidelines are lacking …

Rheumatoid arthritis (RA) is an autoimmune disease accompanied by metabolic alterations.
The metabolic profiles of patients with RA can be determined using targeted and non …

Objective To systematically profile metabolic alterations and dysregulated metabolic
pathways in hyperuricemia and gout, and to identify potential metabolite biomarkers to …

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by extensive
synovitis resulting in erosions of articular cartilage and marginal bone that lead to joint …

Mitochondria are major energy-producing organelles that have central roles in cellular
metabolism. They also act as important signalling hubs, and their dynamic regulation in …

Patients with rheumatoid arthritis (RA) develop features of accelerated ageing, including
immunosenescence. These changes include decreased thymic functionality, expansion of …

Metabolomics enables the profiling of large numbers of small molecules in cells, tissues and
biological fluids. These molecules, which include amino acids, carbohydrates, lipids …