This article reviews the discovery of PCSK9, its structure–function characteristics, and its
presently known and proposed novel biological functions. The major critical function of …

Statins, typically used to reduce lipid levels, have been rediscovered for exhibiting
anticancer activities. Among them, especially simvastatin may influence the proliferation …

Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) is the ninth member of
the proprotein convertase family that regulates lipoprotein homeostasis and altered PCSK9 …

The 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, also known
as statins, are administered as first-line therapy for hypercholesterolemia, both as primary …

Cholesterol homeostasis is essential for healthy mammalian cells and dysregulation of
cholesterol metabolism contributes to the pathogenesis of various diseases including …

Breast cancer is the most common cancer in women, with a high incidence estimated to
reach 2.3 million by 2030. Triple-Negative Breast Cancer (TNBC) is the greatest invasive …

Based on the structural and signaling roles of cholesterol, which are necessary for immune
cell activity, high concentrations of cholesterol and its metabolites not only trigger malignant …

Background The prevalence of dyslipidemia in patients with type 2 diabetes (T2D) has been
reported to be relatively high. The current study aimed to investigate the trend of serum lipid …

Neoplasms of the lungs are the leading cause of cancer incidence and mortality worldwide.
Although immunotherapy has increased the overall survival of patients with lung cancer …

Cancer is a disease with a significant global burden in terms of premature mortality, loss of
productivity, healthcare expenditures, and impact on mental health. Recent decades have …