Cancer immunotherapy has emerged as a novel cancer treatment, although recent
immunotherapy trials have produced suboptimal outcomes, with durable responses seen …

The discovery of microRNAs and their role in diseases was a breakthrough that inspired
research into microRNAs as drug targets. Cardiovascular diseases are an area in which …

Tumour-Associated Macrophages (TAMs) are one of the pivotal components of the tumour
microenvironment. Their roles in the cancer immunity are complicated, both pro-tumour and …

Simple Summary Since the targeting of a single pro-angiogenic factor fails to improve
oncological disease outcome, significant efforts have been made to identify new pro …

It has been almost two decades since the first link between microRNAs and cancer was
established. In the ensuing years, this abundant class of short noncoding regulatory RNAs …

Our understanding of the tumor microenvironment (TME), including the interplay between
tumor cells, stromal cells, immune cells, and extracellular matrix components, is mandatory …

Metastasis is a pivotal event that accelerates the prognosis of cancer patients towards
mortality. Therapies that aim to induce cell death in metastatic cells require a more detailed …

Abstract Angiopoietin-like 4 (ANGPTL4) is known to regulate various cellular and systemic
functions. However, its cell-specific role in endothelial cells (ECs) function and metabolic …

Background Gastric cancer (GC) is one of the deadliest malignant tumors with unknown
pathogenesis. Due to its treatment resistance, high recurrence rate, and lack of reliable early …

Altered metabolic patterns in tumor cells not only meet their own growth requirements but
also shape an immunosuppressive microenvironment through multiple mechanisms …