Metal complexes derived from bidentate ligands: Synthesis, catalytic and biological applications

DI Ugwu, J Conradie - Inorganica Chimica Acta, 2023 - Elsevier
This review focusses on metal complexes containing bidentate ligands. The development in
the synthesis and some applications of these complexes, reported mainly in the last two …

Synthesis, vibrational analysis, molecular property investigation, and molecular docking of new benzenesulphonamide-based carboxamide derivatives against …

UD Izuchukwu, FC Asogwa, H Louis… - Journal of Molecular …, 2022 - Elsevier
Zinc chloride mediated synthesis, density functional theory (DFT) studies and molecular
docking of new carboxamide derivatives containing sulphonamide functionality is reported …

Novel anti-inflammatory and analgesic agents: synthesis, molecular docking and in vivo studies

DI Ugwu, UC Okoro, PO Ukoha, A Gupta… - Journal of enzyme …, 2018 - Taylor & Francis
Twelve new derivatives of benzothiazole bearing benzenesulphonamide and carboxamide
were synthesised and investigated for their in vivo anti-inflammatory, analgesic and …

Design, Synthesis, Molecular Docking, Molecular Dynamics and In Vivo Antimalarial Activity of New Dipeptide‐Sulfonamides

JA Ezugwu, UC Okoro, MA Ezeokonkwo… - …, 2022 - Wiley Online Library
A new series of novel dipeptide sulfonamide analogues were designed, synthesized, and
screened for their in silico studies and in vivo antimalarial activities. The synthesized …

Synthesis, characterization and theoretical investigations on the molecular structure, electronic property and anti-trypanosomal activity of benzenesulphonamide …

FC Asogwa, UD Izuchukwu, H Louis… - Polycyclic Aromatic …, 2023 - Taylor & Francis
Sulfonamide-based carboxamide drugs have multiple active sites that confers them with a
variety of chemical and pharmacological activities. The combination of structural …

Investigation of the Anti-Plasmodial Properties of N-2-Oxo Pyrrolidine Pentanamide-Based Sulfonamides: Experimental and Theoretical Approach

FC Asogwa, O C. Ekoh, D I. Ugwu… - Polycyclic Aromatic …, 2024 - Taylor & Francis
The study aimed to investigate novel pyrrolidine-pentanamide derivatives of sulfonamides
as potential anti-malaria agents through a comprehensive approach involving experimental …

Novel hybrids of quinoline with pyrazolylchalcones as potential antimalarial agents: synthesis, biological evaluation, molecular docking and ADME prediction

A Kumar, S Jain, S Chauhan, S Aggarwal… - Chemico-Biological …, 2023 - Elsevier
A novel series of pyrazolyl chalcones containing quinoline scaffold, 5 av has been
synthesized by Claisen Schimdt condensation of aromatic acetophenone with 1-(4 …

Homology Modelling and Molecular Docking Studies of Selected Substituted Benzo[d]imidazol-1-yl)methyl)benzimidamide Scaffolds on Plasmodium falciparum …

GO Oduselu, OO Ajani, YU Ajamma… - … and biology insights, 2019 - journals.sagepub.com
Plasmodium falciparum adenylosuccinate lyase (Pf ADSL) is an important enzyme in purine
metabolism. Although several benzimidazole derivatives have been commercially …

Synthesis of pyrazole acrylic acid based oxadiazole and amide derivatives as antimalarial and anticancer agents

G Verma, G Chashoo, A Ali, MF Khan, W Akhtar, I Ali… - Bioorganic …, 2018 - Elsevier
Depravity of malaria in terms of morbidity and mortality in human beings makes it a major
health issue in tropical and subtropical areas of the globe. Drug counterfeiting and non …

Synthesis of bis-indolylmethanes as new potential inhibitors of β-glucuronidase and their molecular docking studies

M Taha, H Ullah, LMR Al Muqarrabun, MN Khan… - European Journal of …, 2018 - Elsevier
Abstract Thirty-two (32) bis-indolylmethane-hydrazone hybrids 1–32 were synthesized and
characterized by 1 HNMR, 13 CNNMR and HREI-MS. All compounds were evaluated in vitro …