Extracellular protein components of amyloid plaques and their roles in Alzheimer's disease pathology

MM Rahman, C Lendel - Molecular Neurodegeneration, 2021 - Springer
Alzheimer's disease (AD) is pathologically defined by the presence of fibrillar amyloid β (Aβ)
peptide in extracellular senile plaques and tau filaments in intracellular neurofibrillary …

Alzheimer's disease and type 2 diabetes mellitus: A systematic review of proteomic studies

J Diniz Pereira, V Gomes Fraga… - Journal of …, 2021 - Wiley Online Library
Similar to dementia, the risk for develo** type 2 diabetes mellitus (T2DM) increases with
age, and T2DM also increases the risk for dementia, particularly Alzheimer's disease (AD) …

Ultra-high-throughput clinical proteomics reveals classifiers of COVID-19 infection

CB Messner, V Demichev, D Wendisch, L Michalick… - Cell systems, 2020 - cell.com
The COVID-19 pandemic is an unprecedented global challenge, and point-of-care
diagnostic classifiers are urgently required. Here, we present a platform for ultra-high …

Discovery of autism/intellectual disability somatic mutations in Alzheimer's brains: mutated ADNP cytoskeletal impairments and repair as a case study

Y Ivashko-Pachima, A Hadar, I Grigg, V Korenková… - Molecular …, 2021 - nature.com
With Alzheimer's disease (AD) exhibiting reduced ability of neural stem cell renewal, we
hypothesized that de novo mutations controlling embryonic development, in the form of brain …

Decreased peripheral brain-derived neurotrophic factor levels in Alzheimer's disease: a meta-analysis study (N= 7277)

XY Qin, C Cao, NX Cawley, TT Liu, J Yuan… - Molecular …, 2017 - nature.com
Studies suggest that dysfunction of brain-derived neurotrophic factor (BDNF) is a possible
contributor to the pathology and symptoms of Alzheimer's disease (AD). Several studies …

Chromatin remodeler Activity-Dependent Neuroprotective Protein (ADNP) contributes to syndromic autism

CP D'Incal, KE Van Rossem, K De Man, A Konings… - Clinical …, 2023 - Springer
Background Individuals affected with autism often suffer additional co-morbidities such as
intellectual disability. The genes contributing to autism cluster on a relatively limited number …

Blood-based proteomic biomarkers of Alzheimer's disease pathology

AL Baird, S Westwood, S Lovestone - Frontiers in neurology, 2015 - frontiersin.org
The complexity of Alzheimer's disease (AD) and its long prodromal phase poses challenges
for early diagnosis and yet allows for the possibility of the development of disease modifying …

Proteomics of autism and Alzheimer's mouse models reveal common alterations in mTOR signaling pathway

S Mencer, M Kartawy, F Lendenfeld, H Soluh… - Translational …, 2021 - nature.com
Autism spectrum disorder (ASD) and Alzheimer's disease (AD) are two different neurological
disorders that share common clinical features, such as language impairment, executive …

The NAP motif of activity-dependent neuroprotective protein (ADNP) regulates dendritic spines through microtubule end binding proteins

S Oz, O Kapitansky, Y Ivashco-Pachima… - Molecular …, 2014 - nature.com
The NAP motif of activity-dependent neuroprotective protein (ADNP) enhanced memory
scores in patients suffering from mild cognitive impairment and protected activities of daily …

A subset of autism-associated genes regulate the structural stability of neurons

YC Lin, JA Frei, MBC Kilander, W Shen… - Frontiers in cellular …, 2016 - frontiersin.org
Autism spectrum disorder (ASD) comprises a range of neurological conditions that affect
individuals' ability to communicate and interact with others. People with ASD often exhibit …