[HTML][HTML] Sulforaphane: A broccoli bioactive phytocompound with cancer preventive potential

AE Kaiser, M Baniasadi, D Giansiracusa… - Cancers, 2021 - mdpi.com
Simple Summary As of the past decade, phytochemicals have become a major target of
interest in cancer chemopreventive and chemotherapeutic research. Sulforaphane (SFN) is …

Dietary compounds as epigenetic modulating agents in cancer

Á Carlos-Reyes, JS López-González… - Frontiers in …, 2019 - frontiersin.org
Epigenetic mechanisms control gene expression during normal development and their
aberrant regulation may lead to human diseases including cancer. Natural phytochemicals …

Indoles derived from glucobrassicin: cancer chemoprevention by indole-3-carbinol and 3, 3'-diindolylmethane

DE Williams - Frontiers in Nutrition, 2021 - frontiersin.org
Hydrolysis of glucobrassicin by plant or bacterial myrosinase produces multiple indoles
predominantly indole-3-carbinol (I3C). I3C and its major in vivo product, 3, 3' …

The role of isothiocyanates as cancer chemo-preventive, chemo-therapeutic and anti-melanoma agents

M Mitsiogianni, G Koutsidis, N Mavroudis, DT Trafalis… - Antioxidants, 2019 - mdpi.com
Many studies have shown evidence in support of the beneficial effects of phytochemicals in
preventing chronic diseases, including cancer. Among such phytochemicals, sulphur …

Dietary sulforaphane in cancer chemoprevention: the role of epigenetic regulation and HDAC inhibition

SM Tortorella, SG Royce, PV Licciardi… - Antioxidants & redox …, 2015 - liebertpub.com
Significance: Sulforaphane, produced by the hydrolytic conversion of glucoraphanin after
ingestion of cruciferous vegetables, particularly broccoli and broccoli sprouts, has been …

Mechanisms underlying biological effects of cruciferous glucosinolate-derived isothiocyanates/indoles: a focus on metabolic syndrome

M Esteve - Frontiers in Nutrition, 2020 - frontiersin.org
An inverse correlation between vegetable consumption and the incidence of cancer has
long been described. This protective effect is stronger when cruciferous vegetables are …

[HTML][HTML] Natural bioactive compounds targeting epigenetic pathways in cancer: a review on alkaloids, terpenoids, quinones, and isothiocyanates

N El Omari, S Bakrim, M Bakha, JM Lorenzo… - Nutrients, 2021 - mdpi.com
Cancer is one of the most complex and systemic diseases affecting the health of mankind,
causing major deaths with a significant increase. This pathology is caused by several risk …

[HTML][HTML] Epigenetic regulation of NRF2/KEAP1 by phytochemicals

S Bhattacharjee, RH Dashwood - Antioxidants, 2020 - mdpi.com
Epigenetics has provided a new dimension to our understanding of nuclear factor erythroid
2–related factor 2/Kelch-like ECH-associated protein 1 (human NRF2/KEAP1 and murine …

Dietary glucosinolates sulforaphane, phenethyl isothiocyanate, indole-3-carbinol/3, 3′-diindolylmethane: Antioxidative stress/inflammation, Nrf2, epigenetics …

F Fuentes, X Paredes-Gonzalez, ANT Kong - Current pharmacology …, 2015 - Springer
Glucosinolates are a group of sulfur-containing glycosides found in many plant species,
including cruciferous vegetables such as broccoli, cabbage, Brussels sprouts, and …

[HTML][HTML] Transcriptional changes in prostate of men on active surveillance after a 12-mo glucoraphanin-rich broccoli intervention—results from the Effect of …

MH Traka, A Melchini, J Coode-Bate, O Al Kadhi… - The American journal of …, 2019 - Elsevier
Background Epidemiological evidence suggests that consumption of cruciferous vegetables
is associated with reduced risk of prostate cancer progression, largely attributed to the …