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Extraintestinal manifestations of inflammatory bowel disease: current concepts, treatment, and implications for disease management
Inflammatory bowel diseases (IBDs) are systemic diseases that manifest not only in the gut
and gastrointestinal tract, but also in the extraintestinal organs in many patients. The quality …
and gastrointestinal tract, but also in the extraintestinal organs in many patients. The quality …
Axial spondyloarthritis
Axial spondyloarthritis (axSpA) encompasses both radiographic and non-radiographic
axSpA. It is a chronic inflammatory disease with a predilection for involving the axial …
axSpA. It is a chronic inflammatory disease with a predilection for involving the axial …
ASAS-EULAR recommendations for the management of axial spondyloarthritis: 2022 update
Objectives To update the Assessment of SpondyloArthritis international Society (ASAS)-
EULAR recommendations for the management of axial spondyloarthritis (axSpA). Methods …
EULAR recommendations for the management of axial spondyloarthritis (axSpA). Methods …
Role of the IL-23/IL-17 pathway in rheumatic diseases: an overview
Interleukin-23 (IL-23) is a pro-inflammatory cytokine composed of two subunits, IL-23A (p19)
and IL-12/23B (p40), the latter shared with Interleukin-12 (IL-12). IL-23 is mainly produced …
and IL-12/23B (p40), the latter shared with Interleukin-12 (IL-12). IL-23 is mainly produced …
Upadacitinib for the treatment of active non-radiographic axial spondyloarthritis (SELECT-AXIS 2): a randomised, double-blind, placebo-controlled, phase 3 trial
Summary Background Upadacitinib, a Janus kinase inhibitor, has been shown to be
effective in patients with ankylosing spondylitis. We aimed to assess the efficacy and safety …
effective in patients with ankylosing spondylitis. We aimed to assess the efficacy and safety …
[HTML][HTML] Paracetamol: a review of guideline recommendations
Musculoskeletal pain conditions are age-related, leading contributors to chronic pain and
pain-related disability, which are expected to rise with the rapid global population aging …
pain-related disability, which are expected to rise with the rapid global population aging …
Tofacitinib for the treatment of ankylosing spondylitis: a phase III, randomised, double-blind, placebo-controlled study
Objective To assess the efficacy/safety of tofacitinib in adult patients with active ankylosing
spondylitis (AS). Methods This phase III, randomised, double-blind, placebo-controlled study …
spondylitis (AS). Methods This phase III, randomised, double-blind, placebo-controlled study …
Ankylosing spondylitis: etiology, pathogenesis, and treatments
Ankylosing spondylitis (AS), a common type of spondyloarthropathy, is a chronic
inflammatory autoimmune disease that mainly affects spine joints, causing severe, chronic …
inflammatory autoimmune disease that mainly affects spine joints, causing severe, chronic …
2019 update of EULAR recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseases
V Furer, C Rondaan, MW Heijstek… - Annals of the rheumatic …, 2020 - Elsevier
Abstract To update the European League Against Rheumatism (EULAR) recommendations
for vaccination in adult patients with autoimmune inflammatory rheumatic diseases (AIIRD) …
for vaccination in adult patients with autoimmune inflammatory rheumatic diseases (AIIRD) …
Targeting interleukin-6 signaling in clinic
Interleukin-6 (IL-6) is a pleiotropic cytokine with roles in immunity, tissue regeneration, and
metabolism. Rapid production of IL-6 contributes to host defense during infection and tissue …
metabolism. Rapid production of IL-6 contributes to host defense during infection and tissue …