Pulmonary surfactant: a mighty thin film
Pulmonary surfactant is a critical component of lung function in healthy individuals. It
functions in part by lowering surface tension in the alveoli, thereby allowing for breathing …
functions in part by lowering surface tension in the alveoli, thereby allowing for breathing …
Lipid–protein and protein–protein interactions in the pulmonary surfactant system and their role in lung homeostasis
O Cañadas, B Olmeda, A Alonso… - International journal of …, 2020 - mdpi.com
Pulmonary surfactant is a lipid/protein complex synthesized by the alveolar epithelium and
secreted into the airspaces, where it coats and protects the large respiratory air–liquid …
secreted into the airspaces, where it coats and protects the large respiratory air–liquid …
Mesenchymal Stem Cell exosome delivered Zinc Finger Protein activation of cystic fibrosis transmembrane conductance regulator
Cystic fibrosis is a genetic disorder that results in a multi‐organ disease with progressive
respiratory decline which leads to premature death. Mutations in the cystic fibrosis …
respiratory decline which leads to premature death. Mutations in the cystic fibrosis …
Human surfactant protein SP-A1 and SP-A2 variants differentially affect the alveolar microenvironment, surfactant structure, regulation and function of the alveolar …
The human innate host defense molecules, SP-A1 and SP-A2 variants, differentially affect
survival after infection in mice and in lung transplant patients. SP-A interacts with the …
survival after infection in mice and in lung transplant patients. SP-A interacts with the …
Pathophysiological roles of stress-activated protein kinases in pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is one of the most symptomatic progressive fibrotic lung
diseases, in which patients have an extremely poor prognosis. Therefore, understanding the …
diseases, in which patients have an extremely poor prognosis. Therefore, understanding the …
Molecular and immune signatures, and pathological trajectories of fatal COVID‐19 lungs defined by in situ spatial single‐cell transcriptome analysis
Despite intensive studies during the last 3 years, the pathology and underlying molecular
mechanism of coronavirus disease 2019 (COVID‐19) remain poorly defined. In this study …
mechanism of coronavirus disease 2019 (COVID‐19) remain poorly defined. In this study …
Mouse models of lung-specific SARS-CoV-2 infection with moderate pathological traits
SH Kim, J Kim, JY Jang, H Noh, J Park… - Frontiers in …, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus
disease 2019 (COVID-19) has been a global health concern since 2019. The viral spike …
disease 2019 (COVID-19) has been a global health concern since 2019. The viral spike …
scTenifoldKnk: an efficient virtual knockout tool for gene function predictions via single-cell gene regulatory network perturbation
Gene knockout (KO) experiments are a proven, powerful approach for studying gene
function. However, systematic KO experiments targeting a large number of genes are …
function. However, systematic KO experiments targeting a large number of genes are …
A comprehensive compilation of data on the relationship between surfactant protein-B (SFTPB) polymorphisms and susceptibility to neonatal respiratory distress …
Background This study aims to explore the association between variations in the Surfactant
Protein-B (SFTPB) gene and the risk of neonatal respiratory distress syndrome (NRDS) …
Protein-B (SFTPB) gene and the risk of neonatal respiratory distress syndrome (NRDS) …
Recent progress on surfactant protein A: cellular function in lung and kidney disease development
SD King, SY Chen - American Journal of Physiology-Cell …, 2020 - journals.physiology.org
Pulmonary surfactant is a heterogeneous active surface complex made up of lipids and
proteins. The major glycoprotein in surfactant is surfactant protein A (SP-A), which is …
proteins. The major glycoprotein in surfactant is surfactant protein A (SP-A), which is …