CaMKII (the multifunctional Ca2+ and calmodulin-dependent protein kinase II) is a highly
validated signal for promoting a variety of common diseases, particularly in the …

Ca2+ is a fundamental second messenger in all cell types and is required for numerous
essential cellular functions, including cardiac and skeletal muscle contraction. The …

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited
arrhythmogenic disease occurring in patients with a structurally normal heart: the disease is …

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a stress‐induced cardiac
channelopathy that has a high mortality in untreated patients. Our understanding has grown …

Understanding relationships between heart failure and arrhythmias, important causes of
suffering and sudden death, remains an unmet goal for biomedical researchers and …

Background: Modeling of human arrhythmias with induced pluripotent stem cell–derived
cardiomyocytes has focused on single-cell phenotypes. However, arrhythmias are the …

Cardiac disease is associated with deleterious emission of mitochondrial reactive oxygen
species (mito-ROS), as well as enhanced oxidation and activity of the sarcoplasmic …

Abstract Cardiomyocyte Na+ and Ca 2+ mishandling, upregulated Ca 2+/calmodulin-
dependent kinase II (CaMKII), and increased reactive oxygen species (ROS) are …

Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT), an inherited
cardiac arrhythmia characterized by adrenergically triggered arrhythmias, is inadequately …

Sinus node dysfunction (SND) is a major public health problem that is associated with
sudden cardiac death and requires surgical implantation of artificial pacemakers. However …