Predictive chemistry: machine learning for reaction deployment, reaction development, and reaction discovery

Z Tu, T Stuyver, CW Coley - Chemical science, 2023‏ - pubs.rsc.org
The field of predictive chemistry relates to the development of models able to describe how
molecules interact and react. It encompasses the long-standing task of computer-aided …

Artificial Intelligence for Surface‐Enhanced Raman Spectroscopy

X Bi, L Lin, Z Chen, J Ye - Small Methods, 2024‏ - Wiley Online Library
Surface‐enhanced Raman spectroscopy (SERS), well acknowledged as a fingerprinting
and sensitive analytical technique, has exerted high applicational value in a broad range of …

Retrosynthesis prediction with an interpretable deep-learning framework based on molecular assembly tasks

Y Wang, C Pang, Y Wang, J **, J Zhang… - Nature …, 2023‏ - nature.com
Automating retrosynthesis with artificial intelligence expedites organic chemistry research in
digital laboratories. However, most existing deep-learning approaches are hard to explain …

Recent advances in deep learning for retrosynthesis

Z Zhong, J Song, Z Feng, T Liu, L Jia… - Wiley …, 2024‏ - Wiley Online Library
Retrosynthesis is the cornerstone of organic chemistry, providing chemists in material and
drug manufacturing access to poorly available and brand‐new molecules. Conventional rule …

Retrosynthesis prediction with an iterative string editing model

Y Han, X Xu, CY Hsieh, K Ding, H Xu, R Xu… - Nature …, 2024‏ - nature.com
Retrosynthesis is a crucial task in drug discovery and organic synthesis, where artificial
intelligence (AI) is increasingly employed to expedite the process. However, existing …

Llasmol: Advancing large language models for chemistry with a large-scale, comprehensive, high-quality instruction tuning dataset

B Yu, FN Baker, Z Chen, X Ning, H Sun - arxiv preprint arxiv:2402.09391, 2024‏ - arxiv.org
Chemistry plays a crucial role in many domains, such as drug discovery and material
science. While large language models (LLMs) such as GPT-4 exhibit remarkable …

Dual-view molecular pre-training

J Zhu, Y **a, L Wu, S **e, W Zhou, T Qin, H Li… - Proceedings of the 29th …, 2023‏ - dl.acm.org
Molecular pre-training, which is about to learn an effective representation for molecules on
large amount of data, has attracted substantial attention in cheminformatics and …

Exploring chemical reaction space with machine learning models: Representation and feature perspective

Y Ding, B Qiang, Q Chen, Y Liu… - Journal of Chemical …, 2024‏ - ACS Publications
Chemical reactions serve as foundational building blocks for organic chemistry and drug
design. In the era of large AI models, data-driven approaches have emerged to innovate the …

The impact of large language models on scientific discovery: a preliminary study using gpt-4

MR AI4Science, MA Quantum - arxiv preprint arxiv:2311.07361, 2023‏ - arxiv.org
In recent years, groundbreaking advancements in natural language processing have
culminated in the emergence of powerful large language models (LLMs), which have …

Re-evaluating retrosynthesis algorithms with syntheseus

K Maziarz, A Tripp, G Liu, M Stanley, S **e… - Faraday …, 2025‏ - pubs.rsc.org
Automated synthesis planning has recently re-emerged as a research area at the
intersection of chemistry and machine learning. Despite the appearance of steady progress …