Heparanase-enhanced shedding of syndecan-1 and its role in driving disease pathogenesis and progression
Both heparanase and syndecan-1 are known to be present and active in disease
pathobiology. An important feature of syndecan-1 related to its role in pathologies is that it …
pathobiology. An important feature of syndecan-1 related to its role in pathologies is that it …
SHock-INduced Endotheliopathy (SHINE): A mechanistic justification for viscoelastography-guided resuscitation of traumatic and non-traumatic shock
Irrespective of the reason for hypoperfusion, hypocoagulable and/or hyperfibrinolytic
hemostatic aberrancies afflict up to one-quarter of critically ill patients in shock. Intensivists …
hemostatic aberrancies afflict up to one-quarter of critically ill patients in shock. Intensivists …
[HTML][HTML] Glycocalyx heparan sulfate cleavage promotes endothelial cell angiopoietin-2 expression by impairing shear stress–related AMPK/FoxO1 signaling
RP Richter, AR Ashtekar, L Zheng, D Pretorius… - JCI insight, 2022 - ncbi.nlm.nih.gov
Abstract Angiopoietin-2 (Ang-2) is a key mediator of vascular disease during sepsis, and
elevated plasma levels of Ang-2 are associated with organ injury scores and poor clinical …
elevated plasma levels of Ang-2 are associated with organ injury scores and poor clinical …
[HTML][HTML] Endothelial glycocalyx and cardiomyocyte damage is prevented by recombinant syndecan-1 in acute myocardial infarction
C Vahldieck, E Cianflone, B Fels, S Löning… - The American Journal of …, 2023 - Elsevier
The outer layer of endothelial cells (ECs), consisting of the endothelial glycocalyx (eGC) and
the cortex (CTX), provides a protective barrier against vascular diseases. Structural and …
the cortex (CTX), provides a protective barrier against vascular diseases. Structural and …
Dysregulated complement activation during acute myocardial infarction leads to endothelial glycocalyx degradation and endothelial dysfunction via the C5a: C5a …
C Vahldieck, S Löning, C Hamacher, B Fels… - Frontiers in …, 2024 - frontiersin.org
Introduction Complement-mediated damage to the myocardium during acute myocardial
infarction (AMI), particularly the late components of the terminal pathway (C5-convertase …
infarction (AMI), particularly the late components of the terminal pathway (C5-convertase …
[PDF][PDF] Glycocalyx heparan sulfate cleavage promotes endothelial cell angiopoietin-2 expression
RP Richter, AR Ashtekar, L Zheng, D Pretorius… - Crit Care …, 2012 - Am Soc Clin Investig
ABSTRACT Angiopoietin-2 (Ang-2) is a key mediator of vascular disease during sepsis, and
elevated plasma levels of Ang-2 are associated with organ injury scores and poor clinical …
elevated plasma levels of Ang-2 are associated with organ injury scores and poor clinical …