The role of platelets in immune-mediated inflammatory diseases

M Scherlinger, C Richez, GC Tsokos… - Nature Reviews …, 2023 - nature.com
Immune-mediated inflammatory diseases (IMIDs) are characterized by excessive and
uncontrolled inflammation and thrombosis, both of which are responsible for organ damage …

COVID-19 update: Covid-19-associated coagulopathy

RC Becker - Journal of thrombosis and thrombolysis, 2020 - Springer
The Covid-19 pandemic has introduced an array of organspecific and systemic phenotypes-
some previously observed in viral infections, including severe acute respiratory syndrome …

[HTML][HTML] Elevated calprotectin and abnormal myeloid cell subsets discriminate severe from mild COVID-19

A Silvin, N Chapuis, G Dunsmore, AG Goubet… - Cell, 2020 - cell.com
Blood myeloid cells are known to be dysregulated in coronavirus disease 2019 (COVID-19),
caused by SARS-CoV-2. It is unknown whether the innate myeloid response differs with …

Mechanism of thrombocytopenia in COVID-19 patients

P Xu, Q Zhou, J Xu - Annals of hematology, 2020 - Springer
Since December 2019, a novel coronavirus has spread throughout China and across the
world, causing a continuous increase in confirmed cases within a short period of time. Some …

COVID-19 and multiorgan failure: A narrative review on potential mechanisms

T Mokhtari, F Hassani, N Ghaffari, B Ebrahimi… - Journal of molecular …, 2020 - Springer
The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) in
December 2019 form Wuhan, China leads to coronavirus disease 2019 (COVID-19) …

Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation

SX Gu, T Tyagi, K Jain, VW Gu, SH Lee… - Nature Reviews …, 2021 - nature.com
The core pathology of coronavirus disease 2019 (COVID-19) is infection of airway cells by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that results in excessive …

Platelet factors are induced by longevity factor klotho and enhance cognition in young and aging mice

C Park, O Hahn, S Gupta, AJ Moreno, F Marino, B Kedir… - Nature aging, 2023 - nature.com
Platelet factors regulate wound healing and can signal from the blood to the brain,.
However, whether platelet factors modulate cognition, a highly valued and central …

[HTML][HTML] Platelets contribute to disease severity in COVID‐19

TJ Barrett, S Bilaloglu, M Cornwell, HM Burgess… - Journal of Thrombosis …, 2021 - Elsevier
Objective Heightened inflammation, dysregulated immunity, and thrombotic events are
characteristic of hospitalized COVID‐19 patients. Given that platelets are key regulators of …

The neutrophil's role during health and disease

PX Liew, P Kubes - Physiological reviews, 2019 - journals.physiology.org
Neutrophils have always been considered as uncomplicated front-line troopers of the innate
immune system equipped with limited proinflammatory duties. Yet recently, the role of the …

In vivo editing of lung stem cells for durable gene correction in mice

Y Sun, S Chatterjee, X Lian, Z Traylor, SR Sattiraju… - Science, 2024 - science.org
In vivo genome correction holds promise for generating durable disease cures; yet, effective
stem cell editing remains challenging. In this work, we demonstrate that optimized lung …