Summary Hypoxia-inducible factor (HIF), a central regulator for detecting and adapting to
cellular oxygen levels, transcriptionally activates genes modulating oxygen homeostasis …

Studies of the regulation of erythropoietin (EPO) production by the liver and kidneys, one of
the classical physiological responses to hypoxia, led to the discovery of human oxygen …

Hypoxia‐inducible factor (HIF) is the major transcriptional regulator of cellular responses to
hypoxia. The two principal HIF‐α isoforms, HIF‐1α and HIF‐2α, are progressively stabilized …

Cardiovascular diseases are the leading cause of death worldwide. During the development
of cardiovascular diseases, hypoxia plays a crucial role. Hypoxia-inducible factors (HIFs) are …

Macrophages orchestrate tissue homeostasis and immunity. In the tumor microenvironment
(TME), macrophage presence is largely associated with poor prognosis because of their …

Large-scale human genetic data,–have shown that cancer mutations display strong tissue-
selectivity, but how this selectivity arises remains unclear. Here, using experimental models …

Hypoxic reprogramming of vasculature relies on genetic, epigenetic, and metabolic circuitry,
but the control points are unknown. In pulmonary arterial hypertension (PAH), a disease …

Remote enhancers are thought to interact with their target promoters via physical proximity,
yet the importance of this proximity for enhancer function remains unclear. Here we …

Protein-coding mutations in clear cell renal cell carcinoma (ccRCC) have been extensively
characterized, frequently involving inactivation of the von Hippel–Lindau (VHL) tumor …

High-altitude adaptation of Tibetans represents a remarkable case of natural selection
during recent human evolution. Previous genome-wide scans found many non-coding …