The success of platinum-based anticancer agents has motivated the exploration of novel
metal-based drugs for several decades, whereas problems such as drug-resistance and …

A simple, primary amine bearing a C10H15 alkyl residue was found to display potent anti-
Influenza A properties in 1964. 1 Soon thereafter, antiviral activity of this amine was found …

Despite the widespread use of antineoplastic platinum drugs, a number of accompanying
disadvantages exist. In connection with attempts to circumvent these problems new platinum …

A Schiff base ligand HL,(E)-2-((adamantan-1-ylimino) methyl)-6-allylphenol, was
synthesized by condensation of amantadine with 3-allyl-2-hydroxybenzaldehyde, followed …

Following the serendipitous discovery of the anticancer drug, cisplatin, numerous platinum
(II) complexes have been synthesized and some of them, such as carboplatin, oxaliplatin …

Cisplatin and its platinum (Pt)(II) derivatives play a key role in the fight against various
human cancers such as testicular, ovarian, head and neck, lung tumors. However, their …

This work synthesized and structurally characterized the two adamantan-1-amine-based
compounds, C 10 H 18 N 2 O 3 (1) and C 21 H 23 NO (2), reacting with adamantan-1-amine …

In this work, we explore the use of a quick coupling mechanism for “arming” a cyclodextrin
coated gold nanoparticle (AuNP) delivery vehicle, 2, with an adamantane-oxoplatin …

Most evidence indicates that platinum (IV) prodrugs are rapidly reduced under physiological
conditions by biologically relevant reducing agents, such as ascorbic acid and glutathione; …

The antiproliferative activity of the gold complex [Au (tpp) Cl](1)(tpp= triphenyphosphine)
against human breast adenocarcinoma cells (MCF-7) and normal human fetal lung …