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Genetics of circadian rhythms and sleep in human health and disease
Circadian rhythms and sleep are fundamental biological processes integral to human
health. Their disruption is associated with detrimental physiological consequences …
health. Their disruption is associated with detrimental physiological consequences …
Genome-wide meta-analyses of restless legs syndrome yield insights into genetic architecture, disease biology and risk prediction
Restless legs syndrome (RLS) affects up to 10% of older adults. Their healthcare is impeded
by delayed diagnosis and insufficient treatment. To advance disease prediction and find …
by delayed diagnosis and insufficient treatment. To advance disease prediction and find …
Natural killer cell-derived exosomal miR-1249-3p attenuates insulin resistance and inflammation in mouse models of type 2 diabetes
Y Wang, M Li, L Chen, H Bian, X Chen… - … and Targeted Therapy, 2021 - nature.com
Natural killer (NK) cells have been suggested to be associated with type 2 diabetes by
regulating systemic inflammation. However, the mechanism by which NK cells regulate …
regulating systemic inflammation. However, the mechanism by which NK cells regulate …
Multimodal spatiotemporal transcriptomic resolution of embryonic palate osteogenesis
The terminal differentiation of osteoblasts and subsequent formation of bone marks an
important phase in palate development that leads to the separation of the oral and nasal …
important phase in palate development that leads to the separation of the oral and nasal …
[HTML][HTML] Insulin and IGF-1 elicit robust transcriptional regulation to modulate autophagy in astrocytes
Objective Insulin is a principal metabolic hormone. It regulates a plethora of metabolic
pathways in peripheral tissues. The highly homologous insulin-like growth factor 1 (IGF-1) …
pathways in peripheral tissues. The highly homologous insulin-like growth factor 1 (IGF-1) …
Human α‐synuclein overexpression upregulates SKOR1 in a rat model of simulated nigrostriatal ageing
N Morales‐Prieto, R Bevans, A O'Mahony… - Aging …, 2024 - Wiley Online Library
Parkinson's disease (PD) is characterised by progressive loss of dopaminergic (DA)
neurons from the substantia nigra (SN) and α‐synuclein (αSyn) accumulation. Age is the …
neurons from the substantia nigra (SN) and α‐synuclein (αSyn) accumulation. Age is the …
Molecular analyses of zebrafish V0v spinal interneurons and identification of transcriptional regulators downstream of Evx1 and Evx2 in these cells
SJ England, AK Rusnock, A Mujcic, A Kowalchuk… - Neural …, 2023 - Springer
Background V0v spinal interneurons are highly conserved, glutamatergic, commissural
neurons that function in locomotor circuits. We have previously shown that Evx1 and Evx2 …
neurons that function in locomotor circuits. We have previously shown that Evx1 and Evx2 …
Overexpression of PDSS2-Del2 in HCC promotes tumor metastasis by interacting with macrophages
Hepatocellular carcinoma (HCC) is one of the most frequent solid tumors worldwide.
According to the Global Cancer Statistics 2020, liver cancer remains the third cause of …
According to the Global Cancer Statistics 2020, liver cancer remains the third cause of …
SKOR1 mediates FER kinase-dependent invasive growth of breast cancer cells
LM Sluimer, E Bullock, MAK Rätze… - Journal of cell …, 2023 - journals.biologists.com
High expression of the non-receptor tyrosine kinase FER is an independent prognostic
factor that correlates with poor survival in breast cancer patients. To investigate whether the …
factor that correlates with poor survival in breast cancer patients. To investigate whether the …
NK-derived exosome miR-1249-3p inhibits Mycobacterium tuberculosis survival in macrophages by targeting SKOR1
F Ma, X Wang, Z Qiu, S Ding, W Du, Y Dai, T Ma, L Yue… - Cytokine, 2024 - Elsevier
Abstract Murine Natural Killer cells were cultivated in vitro to isolate NK-derived exosomes.
Subsequent quantification via qPCR confirmed enrichment of miR-1249-3p. Ana-1 murine …
Subsequent quantification via qPCR confirmed enrichment of miR-1249-3p. Ana-1 murine …