Liquid–liquid phase separation (LLPS) is a novel principle for explaining the precise spatial
and temporal regulation in living cells. LLPS compartmentalizes proteins and nucleic acids …

Malignant transformation is characterized by dysregulation of diverse cellular processes that
have been the subject of detailed genetic, biochemical, and structural studies, but only …

Precise gene editing is—or will soon be—in clinical use for several diseases, and more
applications are under development. The programmable nuclease Cas9, directed by a …

Breast cancer is potentially a lethal disease and a leading cause of death in women.
Chemotherapy and radiotherapy are the most frequently used treatment options. Drug …

Homologous recombination (HR) is a highly accurate DNA repair mechanism. Several HR
genes are established cancer susceptibility genes with clinically actionable pathogenic …

Cancer is a disease characterized by uncontrolled cell proliferation, but the precise
pathological mechanisms underlying tumorigenesis often remain to be elucidated. In recent …

DNA double-strand breaks (DSBs) are the fatal type of DNA damage mostly induced by
exposure genome to ionizing radiation or genotoxic chemicals. DSBs are mainly repaired by …

Double-strand breaks (DSBs) are toxic lesions that can be generated by exposure to
genotoxic agents or during physiological processes, such as during V (D) J recombination …

Liquid–liquid Phase Separation (LLPS) of proteins and nucleic acids has emerged as a new
paradigm in the study of cellular activities. It drives the formation of liquid-like condensates …

In response to DNA damage, cells have developed a sophisticated signaling pathway,
consisting of DNA damage sensors, transducers, and effectors, to ensure efficient and …