A central function of the vascular endothelium is to serve as a barrier between the blood and
the surrounding tissue of the body. At the same time, solutes and cells have to pass the …

Platelets have long been recognized as key players in hemostasis and thrombosis;
however, growing evidence suggests that they are also significantly involved in cancer, the …

Current natural killer (NK) cell-based cancer immunotherapy for the treatment of solid tumors
often exhibits insufficient cancer recognition specificity, thereby limiting therapeutic …

Cancer-associated thrombosis is a leading cause of non-cancer death in cancer patients
and is comprised of both arterial and venous thromboembolism (VTE). There are multiple …

Endothelial-to-mesenchymal transition (EndMT) is a process that encompasses extensive
transcriptional reprogramming of activated endothelial cells leading to a shift toward …

Von Willebrand factor (VWF) is a multimeric procoagulant plasma glycoprotein that mediates
platelet adhesion along the endothelium. In addition to its role maintaining normal …

The plasma glycoprotein von Willebrand factor (VWF) is exclusively synthesized in
endothelial cells (ECs) and megakaryocytes, the precursor cells of platelets. Its primary …

The cell membrane-coating strategy has opened new opportunities for the development of
biomimetic and multifunctional drug delivery platforms. Recently, a variety of gold …

Single-cell genomics technologies have accelerated our understanding of cell-state
heterogeneity in diverse contexts. Although single-cell RNA sequencing identifies rare …

Hepatocellular carcinoma (HCC) is a hypervascular malignancy by which its growth and
dissemination are largely driven by the modulation of tumor‐derived small extracellular …