Strategies for overcoming protein and peptide instability in biodegradable drug delivery systems

M Shi, KJ McHugh - Advanced drug delivery reviews, 2023 - Elsevier
The global pharmaceutical market has recently shifted its focus from small molecule drugs to
peptide, protein, and nucleic acid drugs, which now comprise a majority of the top-selling …

Thermostable vaccines: An innovative concept in vaccine development

R Kumar, V Srivastava, P Baindara… - Expert Review of …, 2022 - Taylor & Francis
Introduction Vaccines represent he most common and safer ways of combating infectious
diseases. Loss of potency owing to thermal denaturation or degradation of almost all the …

Blockchain-based solution for distribution and delivery of COVID-19 vaccines

A Musamih, R Jayaraman, K Salah, HR Hasan… - Ieee …, 2021 - ieeexplore.ieee.org
Distribution and delivery of Coronavirus 2019 (COVID-19) vaccines have become
challenging after their emergence. Today's platforms and systems leveraged for managing …

Thermal stabilization of diverse biologics using reversible hydrogels

B Marco-Dufort, JR Janczy, T Hu, M Lütolf, F Gatti… - Science …, 2022 - science.org
Improving the thermal stability of biologics, including vaccines, is critical to reduce the
economic costs and health risks associated with the cold chain. Here, we designed a …

The vaccine supply chain: a call for resilience analytics to support COVID-19 vaccine production and distribution

MS Golan, BD Trump, JC Cegan, I Linkov - COVID-19: systemic risk and …, 2021 - Springer
Pharmaceutical companies, upstream suppliers, associated logistics providers, health
workers, regulatory agencies, public health experts and ultimately the medical practitioners …

[HTML][HTML] Biomimetic metal-organic frameworks as protective scaffolds for live-virus encapsulation and vaccine stabilization

R Singh, JF White, M de Vries, G Beddome, M Dai… - Acta Biomaterialia, 2022 - Elsevier
The invaluable health, economic and social impacts of vaccination are hard to exaggerate.
The ability to stabilize vaccines is urgently required for their equitable distribution without the …

[HTML][HTML] Transforming vaccine development

S Black, DE Bloom, DC Kaslow, S Pecetta… - Seminars in …, 2020 - Elsevier
The urgency to develop vaccines against Covid-19 is putting pressure on the long and
expensive development timelines that are normally required for development of lifesaving …

Development of a formulation platform for a spray-dried, inhalable tuberculosis vaccine candidate

M Gomez, J McCollum, H Wang, M Ordoubadi… - International journal of …, 2021 - Elsevier
Protection against primarily respiratory infectious diseases, such as tuberculosis (TB), can
likely be enhanced through mucosal immunization induced by direct delivery of vaccines to …

An efficient (nano) silica-In glucan particles protein encapsulation approach for improved thermal stability

ER Soto, CA Specht, F Rus, CK Lee, A Abraham… - Journal of Controlled …, 2023 - Elsevier
Glucan particles (GPs) are hollow, porous microspheres derived from Saccharomyces
cerevisiae (Baker's yeast). The hollow cavity of GPs allows for efficient encapsulation of …

[HTML][HTML] Development of stabilizing solution for long-term storage of bacteriophages at room temperature and application to control foodborne pathogens

EJ Kim, MC Lim, MA Woo, BS Kim, JA Lim - Viruses, 2024 - mdpi.com
Bacteriophages (phages) have gained considerable attention as effective antimicrobial
agents that infect and kill pathogenic bacteria. Based on this feature, phages have been …