Glycyrrhizin: An alternative drug for the treatment of COVID-19 infection and the associated respiratory syndrome?

C Bailly, G Vergoten - Pharmacology & therapeutics, 2020 - Elsevier
Safe and efficient drugs to combat the current COVID-19 pandemic are urgently needed. In
this context, we have analyzed the anti-coronavirus potential of the natural product …

Chinese herbal medicine: Fighting SARS-CoV-2 infection on all fronts

Z Wang, L Yang - Journal of Ethnopharmacology, 2021 - Elsevier
Ethnopharmacological relevance Severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) infection causes coronavirus disease 2019 (COVID-19), a highly pathogenic virus …

Combination of vitamin C and curcumin safeguards against methotrexate-induced acute liver injury in mice by synergistic antioxidant effects

D Hasan Khudhair, AI Al-Gareeb… - Frontiers in …, 2022 - frontiersin.org
Methotrexate (MTX), an antineoplastic and immunosuppressive drug, widely used in the
treatment of different types of cancers and the management of chronic inflammatory …

Phytochemical add-on therapy to DMARDs therapy in rheumatoid arthritis: In vitro and in vivo bases, clinical evidence and future trends

G Kour, SA Haq, BK Bajaj, PN Gupta… - Pharmacological Research, 2021 - Elsevier
The use of biologically active compounds derived from plants ie phytochemicals, have been
known for ages for their pharmacological activities in the treatment of autoimmune disorders …

Prevention and management of idiosyncratic drug-induced liver injury: systematic review and meta-analysis of randomised clinical trials

H Niu, JA Sanabria-Cabrera, I Alvarez-Alvarez… - 2021 - riuma.uma.es
Conducting randomised clinical trials (RCTs) in idiosyncratic drug-induced liver injury (DILI)
is challenging. This systematic review aims to summarise the design and findings of RCTs in …

Novel therapies for the treatment of drug-induced liver injury: a systematic review

MS Benić, L Nežić, V Vujić-Aleksić… - Frontiers in …, 2022 - frontiersin.org
Many drugs with different mechanisms of action and indications available on the market
today are capable of inducing hepatotoxicity. Drug-induced liver injury (DILI) has been a …

Spirulina and thymoquinone protect against methotrexate-induced hepatic injury in rats

A Behairy, A Elkomy, F Elsayed, MMS Gaballa… - Revista Brasileira de …, 2024 - Springer
Methotrexate is a chemotherapy medication frequently used to treat various forms of cancer.
The purpose of this research was to examine if the administration of Arthrospira platensis …

Surface saturation of drug-loaded hollow manganese dioxide nanoparticles with human serum albumin for treating rheumatoid arthritis

M Jia, W Ren, M Wang, Y Liu, C Wang, Z Zhang… - Drug Delivery, 2024 - Taylor & Francis
Rheumatoid arthritis (RA) is a chronic inflammatory joint disease accompanied by energy
depletion and accumulation of reactive oxygen species (ROS). Inorganic nanoparticles …

Hepatoprotective effect of acetovanillone against methotrexate hepatotoxicity: Role of Keap‐1/Nrf2/ARE, IL6/STAT‐3, and NF‐κB/AP‐1 signaling pathways

OAM Abd El‐Ghafar, EHM Hassanein… - Phytotherapy …, 2022 - Wiley Online Library
This study targeted to examine the protective effects of acetovanillone (AV) against
methotrexate (MTX)‐induced hepatotoxicity. Thirty‐two rats were allocated into four groups …

Targeting inflammation and redox aberrations by perindopril attenuates methotrexate-induced intestinal injury in rats: Role of TLR4/NF-κB and c-Fos/c-Jun pro …

AM Sayed, MM Abdel-Fattah, HH Arab… - Chemico-Biological …, 2022 - Elsevier
Aims The use of methotrexate (MTX), a classical immunosuppressant and anti-cancer agent,
is associated with multiple organ toxicities, including the intestinal injury. Components of the …