As the home of cellular genetic information, the nucleus has a critical role in determining cell
fate and function in response to various signals and stimuli. In addition to biochemical …

Energy deprivation is a frequent adverse event in tumors that is caused by mutations,
malperfusion, hypoxia, and nutrition deficit. The resulting bioenergetic stress leads to …

Mechanobiology is a rapidly growing research area focused on how mechanical forces and
properties influence biological systems at the cell, molecular, and tissue level, and how …

Cell migration occurs in confined microenvironments, which plays a vital role in the process
of tumor metastasis. However, it is challenging to study their behaviors in vivo. Here we …

Metastatic progression is the deadliest feature of cancer. Cancer cell growth, invasion,
intravasation, circulation, arrest/adhesion and extravasation require specific mechanical …

The mechanical properties of the nucleus influence different cellular and nuclear functions
and have relevant implications for several human diseases. The nucleus protects genetic …

Cell and organelle shape are driven by diverse genetic and environmental factors and thus
accurate quantification of cellular morphology is essential to experimental cell biology …

Eukaryotic cells show an astounding ability to remodel their shape and cytoskeleton and to
migrate through pores and constrictions smaller than their nuclear diameter. However, the …

Abstract Development and disease are regulated by the interplay between genetics and the
signaling pathways stimulated by morphogens, growth factors, and cytokines. Experimental …

It is increasingly appreciated that the cell nucleus is not only a home for DNA but also a
complex material that resists physical deformations and dynamically responds to external …