The re-emergence of natural products for drug discovery in the genomics era
Natural products have been a rich source of compounds for drug discovery. However, their
use has diminished in the past two decades, in part because of technical barriers to …
use has diminished in the past two decades, in part because of technical barriers to …
Advances in decomposing complex metabolite mixtures using substructure-and network-based computational metabolomics approaches
Covering: up to the end of 2020 Recently introduced computational metabolome mining
tools have started to positively impact the chemical and biological interpretation of …
tools have started to positively impact the chemical and biological interpretation of …
Accelerating metabolite identification in natural product research: toward an ideal combination of liquid chromatography–high-resolution tandem mass spectrometry …
Natural product research aims to characterize specialized metabolites from various living
organisms and assess their biological properties from either a chemical ecology or drug …
organisms and assess their biological properties from either a chemical ecology or drug …
Dereplication strategies in natural product research: How many tools and methodologies behind the same concept?
The development of new drugs will certainly benefit from an ever improving knowledge of
the living beings chemistry. However, identification of drugable molecules within the …
the living beings chemistry. However, identification of drugable molecules within the …
The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research
JB McAlpine, SN Chen, A Kutateladze… - Natural product …, 2019 - pubs.rsc.org
Covering: up to 2018 With contributions from the global natural product (NP) research
community, and continuing the Raw Data Initiative, this review collects a comprehensive …
community, and continuing the Raw Data Initiative, this review collects a comprehensive …
Combined LC/UV/MS and NMR strategies for the dereplication of marine natural products
I Pérez-Victoria, J Martín, F Reyes - Planta medica, 2016 - thieme-connect.com
Drug discovery from marine natural products has experienced a revival since the beginning
of this century. To be successful in this field, rapid dereplication (identification of already …
of this century. To be successful in this field, rapid dereplication (identification of already …
Identification and structure elucidation by NMR spectroscopy
M Elyashberg - TrAC Trends in Analytical Chemistry, 2015 - Elsevier
The state of the art and recent developments in application of nuclear magnetic resonance
(NMR) for structure elucidation and identification of small organic molecules are discussed …
(NMR) for structure elucidation and identification of small organic molecules are discussed …
Artificial intelligence-guided discovery of anticancer lead compounds from plants and associated microorganisms
G Li, P Lin, K Wang, CC Gu, S Kusari - Trends in Cancer, 2022 - cell.com
Plants and associated microorganisms are essential sources of natural products against
human cancer diseases, partly exemplified by plant-derived anticancer drugs such as Taxol …
human cancer diseases, partly exemplified by plant-derived anticancer drugs such as Taxol …
Emerging new strategies for successful metabolite identification in metabolomics
This review discusses strategies for the identification of metabolites in complex biological
mixtures, as encountered in metabolomics, which have emerged in the recent past. These …
mixtures, as encountered in metabolomics, which have emerged in the recent past. These …
Deep learning-based method for compound identification in NMR spectra of mixtures
W Wei, Y Liao, Y Wang, S Wang, W Du, H Lu, B Kong… - Molecules, 2022 - mdpi.com
Nuclear magnetic resonance (NMR) spectroscopy is highly unbiased and reproducible,
which provides us a powerful tool to analyze mixtures consisting of small molecules …
which provides us a powerful tool to analyze mixtures consisting of small molecules …