Remarkable progress in ageing research has been achieved over the past decades.
General perceptions and experimental evidence pinpoint that the decline of physical …

Over the last several decades, it has become clear that epigenetic abnormalities may be one
of the hallmarks of cancer. Posttranslational modifications of histones, for example, may play …

Ageing is a plastic process and can be successfully modulated by some biomedical
approaches or pharmaceutics. In this manner it is possible to delay or even prevent some …

DNA double-strand breaks (DSBs) arise regularly in cells and when left unrepaired cause
senescence or cell death. Homologous recombination (HR) and nonhomologous end …

NAD+ is a fundamental molecule in human life and health as it participates in energy
metabolism, cell signalling, mitochondrial homeostasis, and in dictating cell survival or …

Recombinational DNA repair is a universal aspect of DNA metabolism and is essential for
genomic integrity. It is a template-directed process that uses a second chromosomal copy …

The sirtuins (SIRTs; of which there are seven in mammals) are NAD+-dependent enzymes
that regulate a large number of cellular pathways and forestall the progression of ageing …

DNA double-strand breaks (DSBs) are highly toxic lesions that can drive genetic instability.
To preserve genome integrity, organisms have evolved several DSB repair mechanisms, of …

Poly (ADP-ribose) polymerase inhibitors (PARPi) are selectively active in cells with
homologous recombination (HR) deficiency (HRD) caused by mutations in BRCA1, BRCA2 …

Mitochondrial dysfunction is a hallmark of ageing, and mitochondrial maintenance may lead
to increased healthspan. Emerging evidence suggests a crucial role for signalling from the …