Emerging concepts of type I interferons in SLE pathogenesis and therapy

A Psarras, M Wittmann, EM Vital - Nature reviews Rheumatology, 2022 - nature.com
Type I interferons have been suspected for decades to have a crucial role in the
pathogenesis of systemic lupus erythematosus (SLE). Evidence has now overturned several …

Interdisciplinary gene manipulation, molecular cloning, and recombinant expression of modified human growth hormone isoform-1 in E. coli system

SM Nasr, S Samir, H Okasha - International Journal of Biological …, 2024 - Elsevier
Background Growth hormone (GH) is a hormone that promotes growth, cell reproduction,
and cell restoration in humans and animals. Objectives Production of recombinant human …

Urinary biomarkers analysis as a diagnostic tool for early detection of pancreatic adenocarcinoma: molecular quantification approach

S Samir, M El-Ashry, W Soliman, M Hassan - Computational Biology and …, 2024 - Elsevier
Background and aims Pancreatic ductal adenocarcinoma (PDAC) is infrequent. Currently,
non-invasive biomarkers for early detection of PDAC are not accessible. Here, we intended …

Phages for treatment of Staphylococcus aureus infection

S Samir - Progress in Molecular Biology and Translational …, 2023 - Elsevier
Combating multi-drug resistant bacterial infections should be a universal urgency. The gram-
positive Staphylococcus aureus (S. aureus) bacteria are generally harmless; healthy people …

Purified recombinant human Chromogranin A N46 peptide with remarkable anticancer effect on human colon cancer cells

H Okasha, S Samir, SM Nasr - Bioorganic Chemistry, 2021 - Elsevier
Abstract Human Chromogranin A N46 (CGA-N46) is a weak cationic α-helical peptide with
wide-spectrum antibacterial, fungal, and anticancer activities. In this study, the recombinant …

Soluble receptor isoform of IFN-beta (sIFNAR2) in multiple sclerosis patients and their association with the clinical response to IFN-beta treatment

P Aliaga-Gaspar, I Hurtado-Guerrero… - Frontiers in …, 2021 - frontiersin.org
Purpose Interferon beta receptor 2 subunit (IFNAR2) can be produced as a transmembrane
protein, but also as a soluble form (sIFNAR2) generated by alternative splicing or proteolytic …

Development of a Novel Peptide with RGD Tumor Homing Motif: Evaluation of its Anticancer Potential in Hepatocellular Carcinoma and Colon Cancer Cells

RA Mohamed, OM Marie, DI Badran… - Recent Patents on …, 2025 - benthamdirect.com
Background Peptide-based therapy has emerged as a promising avenue for treating various
disorders, and recent research has highlighted the potential of anti-cancer peptides (ACPs) …

[HTML][HTML] GC-MS analysis, anti-inflammatory and anti-proliferative properties of the aerial parts of three Mesembryanthemum spp.

HR Mohamed, MM Hamed, EA El-Wakil, H Okasha - Toxicology Reports, 2024 - Elsevier
Background Due to their variability and safety, widespread research on phytochemicals
continually encourages researchers to study various plants for their potential health benefits …

[HTML][HTML] Identification and exploration of anticancer activity of novel peptides isolated from the edible bivalve Callista chione in hepatic and colon cancer cell lines

AAA Hussein, H Okasha, M ElZallat, SI Ghoname… - Toxicology Reports, 2025 - Elsevier
Background The requirement for relevant and safe drugs for cancer treatment is considered
a challenge. Recently, marine isolated compounds with various therapeutic targets have …

Assessing the diagnostic potential of SATB2 and β-catenin as biomarkers and therapeutic targets in pancreatic ductal adenocarcinoma

NS Helal, S Maher, S Samir, HA Elmeligy… - Journal of Cancer …, 2025 - Springer
Methods We analyzed 44 paraffin-embedded tissue blocks along with corresponding blood
and pancreatic tissues. We evaluated SATB2 expression using immunohistochemistry (IHC) …