Size-Dependent In Vivo Transport of Nanoparticles: Implications for Delivery, Targeting, and Clearance
Understanding the in vivo transport of nanoparticles provides guidelines for designing
nanomedicines with higher efficacy and fewer side effects. Among many factors, the size of …
nanomedicines with higher efficacy and fewer side effects. Among many factors, the size of …
Current trends and challenges in cancer management and therapy using designer nanomaterials
Nanotechnology has the potential to circumvent several drawbacks of conventional
therapeutic formulations. In fact, significant strides have been made towards the application …
therapeutic formulations. In fact, significant strides have been made towards the application …
The development of anticancer ruthenium (II) complexes: from single molecule compounds to nanomaterials
Cancer is rapidly becoming the top killer in the world. Most of the FDA approved anticancer
drugs are organic molecules, while metallodrugs are very scarce. The advent of the first …
drugs are organic molecules, while metallodrugs are very scarce. The advent of the first …
Rational design of cancer nanomedicine: nanoproperty integration and synchronization
Current cancer nanomedicines can only mitigate adverse effects but fail to enhance
therapeutic efficacies of anticancer drugs. Rational design of next‐generation cancer …
therapeutic efficacies of anticancer drugs. Rational design of next‐generation cancer …
Intelligent Albumin-MnO2 Nanoparticles as pH-/H2 O2-Responsive Dissociable Nanocarriers to Modulate Tumor Hypoxia for Effective Combination Therapy.
A unique type of pH/H2 O2 dual-responsive intelligent nanoscale delivery system based on
albumin-coated MnO2 is presented, which is capable of modulating the tumor …
albumin-coated MnO2 is presented, which is capable of modulating the tumor …
3D tumor spheroids: an overview on the tools and techniques used for their analysis
In comparison with 2D cell culture models, 3D spheroids are able to accurately mimic some
features of solid tumors, such as their spatial architecture, physiological responses …
features of solid tumors, such as their spatial architecture, physiological responses …
Three-dimensional spheroids as in vitro preclinical models for cancer research
Most cancer biologists still rely on conventional two-dimensional (2D) monolayer culture
techniques to test in vitro anti-tumor drugs prior to in vivo testing. However, the vast majority …
techniques to test in vitro anti-tumor drugs prior to in vivo testing. However, the vast majority …
Gold nanoparticle‐mediated photothermal therapy: applications and opportunities for multimodal cancer treatment
Photothermal therapy (PTT), in which nanoparticles embedded within tumors generate heat
in response to exogenously applied laser light, has been well documented as an …
in response to exogenously applied laser light, has been well documented as an …
Strategies to improve the EPR effect: A mechanistic perspective and clinical translation
Many efforts have been made to achieve targeted delivery of anticancer drugs to enhance
their efficacy and to reduce their adverse effects. These efforts include the development of …
their efficacy and to reduce their adverse effects. These efforts include the development of …
Gold nanoparticles for applications in cancer radiotherapy: Mechanisms and recent advancements
Gold nanoparticles (AuNPs) have emerged as novel radiosensitizers owing to their high X-
ray absorption, synthetic versatility, and unique chemical, electronic and optical properties …
ray absorption, synthetic versatility, and unique chemical, electronic and optical properties …