[HTML][HTML] Indole compounds in oncology: therapeutic potential and mechanistic insights
Cancer remains a formidable global health challenge, with current treatment modalities such
as chemotherapy, radiotherapy, surgery, and targeted therapy often hindered by low efficacy …
as chemotherapy, radiotherapy, surgery, and targeted therapy often hindered by low efficacy …
Antineoplastic indole-containing compounds with potential VEGFR inhibitory properties
DR Aboshouk, MA Youssef, MS Bekheit, AR Hamed… - RSC …, 2024 - pubs.rsc.org
Cancer is one of the most significant health challenges worldwide. Various techniques, tools
and therapeutics/materials have been developed in the last few decades for the treatment of …
and therapeutics/materials have been developed in the last few decades for the treatment of …
Design, synthesis, and antihypertensive activity of new pyrimidine derivatives endowing new pharmacophores
A new series of achiral pyrimidine derivatives based on nifedipine-like structure was
designed and synthesized. These pyrimidyl derivatives contained hydrazine, hydrazones …
designed and synthesized. These pyrimidyl derivatives contained hydrazine, hydrazones …
Design, synthesis and vasorelaxant evaluation of novel coumarin–pyrimidine hybrids
The main objective of the present work depends on the hybridization of coumarin moiety as
a vasorelaxant scaffold and pyrimidine ring with known potential cardiovascular activity in …
a vasorelaxant scaffold and pyrimidine ring with known potential cardiovascular activity in …
Design, synthesis and QSAR studies of dispiroindole derivatives as new antiproliferative agents
Abstract A variety of 4′-aryl-3-(arylmethylidene)-1 ″-[(cyclic-amino) methylene]-1′-methyl-
dispiro [cyclohexane-1, 3′-pyrrolidine-2′, 3 ″-[3H] indole]-2, 2 ″(1 ″H)-diones 4a–u …
dispiro [cyclohexane-1, 3′-pyrrolidine-2′, 3 ″-[3H] indole]-2, 2 ″(1 ″H)-diones 4a–u …
New pyridine and chromene scaffolds as potent vasorelaxant and anticancer agents
Based on studies that have reported the association between cancer and cardiovascular
diseases, new series of pyridine-(3a–o) and/or chromene-(4a–e) carbonitrile analogous …
diseases, new series of pyridine-(3a–o) and/or chromene-(4a–e) carbonitrile analogous …
Synthesis, vasorelaxant activity, and molecular modeling study of some new phthalazine derivatives
FM Awadallah, WI El-Eraky, DO Saleh - European journal of medicinal …, 2012 - Elsevier
New phthalazine-based vasodilators were synthesized through the chloroacylation of the
starting compound 1-hydrazinophthalazine 4 to give the two key intermediates 5 and 7 …
starting compound 1-hydrazinophthalazine 4 to give the two key intermediates 5 and 7 …
Design and synthesis of antiproliferative 2-oxoindolin-3-ylidenes incorporating urea function with potential VEGFR-2 inhibitory properties
Targeted therapy is preferable over other therapeutics due to its limitation of drawbacks and
better pharmaceutical outcomes. VEGF and its receptors have been observed to be hyper …
better pharmaceutical outcomes. VEGF and its receptors have been observed to be hyper …
Molecular modeling study and synthesis of quinazolinone-arylpiperazine derivatives as α1-adrenoreceptor antagonists
Three series of new 2-[(4-substituted piperazin-1-yl) methyl] quinazolin-4 (3H)-ones 4a–c,
Ethyl 6, 7-dimethoxy-4-oxo-3-[2-(4-substituted piperazin-1-yl) acetamido/propanamido]-3, 4 …
Ethyl 6, 7-dimethoxy-4-oxo-3-[2-(4-substituted piperazin-1-yl) acetamido/propanamido]-3, 4 …
Interfacial behavior of modified nicotinic acid as conventional/gemini surfactants
We report the synthesis and monolayer properties of conventional and gemini surfactants
composed of nicotinic acid-based head groups with an emphasis on assessing how …
composed of nicotinic acid-based head groups with an emphasis on assessing how …