Tuberculosis: pathogenesis, current treatment regimens and new drug targets

SSR Alsayed, H Gunosewoyo - International journal of molecular …, 2023 - mdpi.com
Mycobacterium tuberculosis (M. tb), the causative agent of TB, is a recalcitrant pathogen that
is rife around the world, latently infecting approximately a quarter of the worldwide …

Mycolic acids: structures, biosynthesis, and beyond

H Marrakchi, MA Lanéelle, M Daffé - Chemistry & biology, 2014 - cell.com
Mycolic acids are major and specific lipid components of the mycobacterial cell envelope
and are essential for the survival of members of the genus Mycobacterium that contains the …

Mycobacterial cell wall biosynthesis: a multifaceted antibiotic target

KA Abrahams, GS Besra - Parasitology, 2018 - cambridge.org
Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis (TB), is recognized
as a global health emergency as promoted by the World Health Organization. Over 1 million …

The thick waxy coat of mycobacteria, a protective layer against antibiotics and the host's immune system

SM Batt, DE Minnikin, GS Besra - Biochemical Journal, 2020 - portlandpress.com
Tuberculosis, caused by the pathogenic bacterium Mycobacterium tuberculosis (Mtb), is the
leading cause of death from an infectious disease, with a mortality rate of over a million …

[HTML][HTML] New tuberculosis drug targets, their inhibitors, and potential therapeutic impact

GS Shetye, SG Franzblau, S Cho - Translational Research, 2020 - Elsevier
The current tuberculosis (TB) predicament poses numerous challenges and therefore every
incremental scientific work and all positive socio-political engagements, are steps taken in …

[KSIĄŻKA][B] Practical handbook of microbiology

LH Green, E Goldman - 2021 - books.google.com
Practical Handbook of Microbiology, 4th edition provides basic, clear and concise
knowledge and practical information about working with microorganisms. Useful to anyone …

Pathway to Synthesis and Processing of Mycolic Acids in Mycobacterium tuberculosis

K Takayama, C Wang, GS Besra - Clinical microbiology reviews, 2005 - journals.asm.org
Mycobacterium tuberculosis is known to synthesize α-, methoxy-, and keto-mycolic acids.
We propose a detailed pathway to the biosynthesis of all mycolic acids in M. tuberculosis …

Contextual control of skin immunity and inflammation by Corynebacterium

VK Ridaura, N Bouladoux, J Claesen… - Journal of Experimental …, 2018 - rupress.org
How defined microbes influence the skin immune system remains poorly understood. Here
we demonstrate that Corynebacteria, dominant members of the skin microbiota, promote a …

Direct visualization of the outer membrane of mycobacteria and corynebacteria in their native state

B Zuber, M Chami, C Houssin, J Dubochet… - Journal of …, 2008 - journals.asm.org
The cell envelope of mycobacteria, which include the causative agents of tuberculosis and
leprosy, is crucial for their success as pathogens. Despite a continued strong emphasis on …

Biosynthesis and function of polyacetylenes and allied natural products

RE Minto, BJ Blacklock - Progress in lipid research, 2008 - Elsevier
Polyacetylenic natural products are a substantial class of often unstable compounds
containing a unique carbon–carbon triple bond functionality, that are intriguing for their wide …