▪ Abstract The endoplasmic reticulum (ER) and the Golgi comprise the first two steps in
protein secretion. Vesicular carriers mediate a continuous flux of proteins and lipids between …

Intracellular vesicle trafficking is the fundamental process to maintain the homeostasis of
membrane-enclosed organelles in eukaryotic cells. These organelles transport cargo from …

Small G proteins play a central role in the organization of the secretory and endocytic
pathways. The majority of such small G proteins are members of the Rab family, which are …

▪ Abstract Clathrin-coated vesicles (CCVs) are responsible for the transport of proteins
between various compartments of the secretory and endocytic systems. Clathrin forms a …

COPI-coated vesicles mediate trafficking within the Golgi apparatus and from the Golgi to the
endoplasmic reticulum. The structures of membrane protein coats, including COPI, have …

Transport of membranes and proteins in eukaryotic cells is mediated by vesicular carriers.
Here we review the biogenesis and functions of COPI vesicles, carriers that operate in the …

ArfGAP1 promotes GTP hydrolysis in Arf1, a small G protein that interacts with lipid
membranes and drives the assembly of the COPI coat in a GTP‐dependent manner. The …

H-NS and Lsr2 are nucleoid-associated proteins from Gram-negative bacteria and
Mycobacteria, respectively, that play an important role in the silencing of horizontally …

The coat protein complex I (COPI) allows the precise sorting of lipids and proteins between
Golgi cisternae and retrieval from the Golgi to the ER. This essential role maintains the …

Transport of material within cells is mediated by trafficking vesicles that bud from one cellular
compartment and fuse with another. Formation of a trafficking vesicle is driven by membrane …