Dissipative DNA nanotechnology

E Del Grosso, E Franco, LJ Prins, F Ricci - Nature Chemistry, 2022 - nature.com
DNA nanotechnology has emerged as a powerful tool to precisely design and control
molecular circuits, machines and nanostructures. A major goal in this field is to build devices …

Dynamic reconfigurable DNA nanostructures, networks and materials

J Wang, Z Li, I Willner - Angewandte Chemie International …, 2023 - Wiley Online Library
DNA nanotechnology relies on the structural and functional information encoded in nucleic
acids. Specifically, the sequence‐guided reconfiguration of nucleic acids by auxiliary …

Diversity in the dynamical behaviour of a compartmentalized programmable biochemical oscillator

M Weitz, J Kim, K Kapsner, E Winfree, E Franco… - Nature …, 2014 - nature.com
In vitro compartmentalization of biochemical reaction networks is a crucial step towards
engineering artificial cell-scale devices and systems. At this scale the dynamics of molecular …

Synthetic in vitro transcriptional oscillators

J Kim, E Winfree - Molecular systems biology, 2011 - embopress.org
The construction of synthetic biochemical circuits from simple components illuminates how
complex behaviors can arise in chemistry and builds a foundation for future biological …

Timing molecular motion and production with a synthetic transcriptional clock

E Franco, E Friedrichs, J Kim, R Jungmann… - Proceedings of the …, 2011 - pnas.org
The realization of artificial biochemical reaction networks with unique functionality is one of
the main challenges for the development of synthetic biology. Due to the reduced number of …

Dynamic self-assembly of compartmentalized DNA nanotubes

S Agarwal, MA Klocke, PE Pungchai… - Nature communications, 2021 - nature.com
Bottom-up synthetic biology aims to engineer artificial cells capable of responsive behaviors
by using a minimal set of molecular components. An important challenge toward this goal is …

Building in vitro transcriptional regulatory networks by successively integrating multiple functional circuit modules

SW Schaffter, R Schulman - Nature chemistry, 2019 - nature.com
The regulation of cellular dynamics and responses to stimuli by genetic regulatory networks
suggests how in vitro chemical reaction networks might analogously direct the dynamics of …

Bottom-up construction of in vitro switchable memories

A Padirac, T Fujii, Y Rondelez - Proceedings of the National Academy of …, 2012 - pnas.org
Reaction networks displaying bistability provide a chemical mechanism for long-term
memory storage in cells, as exemplified by many epigenetic switches. These biological …

Phototriggered equilibrated and transient orthogonally operating constitutional dynamic networks guiding biocatalytic cascades

Y Ouyang, I Willner - Journal of the American Chemical Society, 2024 - ACS Publications
The photochemical deprotection of structurally engineered o-nitrobenzylphosphate-caged
hairpin nucleic acids is introduced as a versatile method to evolve constitutional dynamic …

Developmental assembly of multi-component polymer systems through interconnected synthetic gene networks in vitro

D Sorrentino, S Ranallo, F Ricci, E Franco - Nature Communications, 2024 - nature.com
Living cells regulate the dynamics of developmental events through interconnected
signaling systems that activate and deactivate inert precursors. This suggests that similarly …