Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults and the
second most common form of acute leukemia in children. Despite this, very little …

Mitochondria have emerged as important pharmacological targets because of their key role
in cellular proliferation and death. In tumor tissues, mitochondria can switch metabolic …

Mitophagy, the selective engulfment and clearance of mitochondria, is essential for the
homeostasis of a healthy network of functioning mitochondria and prevents excessive …

Purpose: Within heterogeneous tumors, subpopulations often labeled cancer stem cells
(CSC) have been identified that have enhanced tumorigenicity and chemoresistance in ex …

Cancer stem cells (CSCs) are a small and elusive subpopulation of self-renewing cancer
cells with remarkable ability to initiate, propagate, and spread the malignant disease. In …

Here, we show that new mitochondrial biogenesis is required for the anchorage
independent survival and propagation of cancer stem-like cells (CSCs). More specifically …

The imprinted, developmentally regulated H19 long noncoding RNA has been implicated in
the pathogenesis of diverse human cancers, but the underlying mechanisms have remained …

Because dormant cancer cells in hypoxic and nutrient-deprived regions of solid tumors
provide a major obstacle to treatment, compounds targeting those cells might have clinical …

Mitochondria are the respiratory and energetic centers of the cell where multiple intra-and
extracellular signal transduction pathways converge leading to dysfunction of those …

Despite medical advances made over the past decade, ovarian cancer remains one of the
more lethal gynecologic cancers in the United States. While current therapeutic strategies …