Great progress has been made in recent years to reduce the high level of suffering caused
by malaria worldwide. Notably, the use of insecticide-treated mosquito nets for malaria …

Conspectus “Drug resistance is an unavoidable consequence of the use of drugs; however,
the emergence of multi-drug resistance can be managed by accurate diagnosis and tailor …

Despite substantial scientific progress over the past two decades, malaria remains a
worldwide burden that causes hundreds of thousands of deaths every year. New, affordable …

Screening of small-molecule libraries is a productive method for identifying both chemical
probes of disease-related targets and potential starting points for drug discovery. In this …

As part of the global effort toward malaria eradication, phenotypic whole-cell screening
revealed the 2-aminopyridine class of small molecules as a good starting point to develop …

Antimalarial drugs have thus far been chiefly derived from two sources—natural products
and synthetic drug-like compounds. Here we investigate whether antimalarial agents with …

Malaria elimination has recently been reinstated as a global health priority but current
therapies seem to be insufficient for the task. Elimination efforts require new drug classes …

The atropselective iodination of 2-amino-6-arylpyridines catalyzed by chiral disulfonimides
(DSIs) is described. Key to the development of this transformation was the use of a …

The unique relapsing nature of Plasmodium vivax infection is a major barrier to malaria
eradication. Upon infection, dormant liver-stage forms, hypnozoites, linger for weeks to …

Growth factor signaling pathways are tightly regulated by phosphorylation and include many
important kinase targets of interest for drug discovery. Small molecule inhibitors of the bone …