Browning of the white adipose tissue regulation: New insights into nutritional and metabolic relevance in health and diseases

SA Machado, G Pasquarelli-do-Nascimento… - Nutrition & …, 2022 - Springer
Adipose tissues are dynamic tissues that play crucial physiological roles in maintaining
health and homeostasis. Although white adipose tissue and brown adipose tissue are …

Sex differences in brown adipose tissue function: sex hormones, glucocorticoids, and their crosstalk

K Kaikaew, A Grefhorst, JA Visser - Frontiers in endocrinology, 2021 - frontiersin.org
Excessive fat accumulation in the body causes overweight and obesity. To date, research
has confirmed that there are two types of adipose tissue with opposing functions: lipid …

[HTML][HTML] Light modulates glucose metabolism by a retina-hypothalamus-brown adipose tissue axis

JJ Meng, JW Shen, G Li, CJ Ouyang, JX Hu, ZS Li… - Cell, 2023 - cell.com
Public health studies indicate that artificial light is a high-risk factor for metabolic disorders.
However, the neural mechanism underlying metabolic modulation by light remains elusive …

[HTML][HTML] Altered brown fat thermoregulation and enhanced cold-induced thermogenesis in young, healthy, winter-swimming men

S Søberg, J Löfgren, FE Philipsen, M Jensen… - Cell Reports …, 2021 - cell.com
The Scandinavian winter-swimming culture combines brief dips in cold water with hot sauna
sessions, with conceivable effects on body temperature. We study thermogenic brown …

Seasonal light hours modulate peripheral clocks and energy metabolism in mice

L Small, LS Lundell, J Iversen, AM Ehrlich, M Dall… - Cell Metabolism, 2023 - cell.com
Except for latitudes close to the equator, seasonal variation in light hours can change
dramatically between summer and winter. Yet investigations into the interplay between …

Lipolysis regulates major transcriptional programs in brown adipocytes

LK Markussen, EA Rondini, OS Johansen… - Nature …, 2022 - nature.com
Abstract β-Adrenergic signaling is a core regulator of brown adipocyte function stimulating
both lipolysis and transcription of thermogenic genes, thereby expanding the capacity for …

NAMPT-dependent NAD+ biosynthesis controls circadian metabolism in a tissue-specific manner

AL Basse, KN Nielsen, I Karavaeva… - Proceedings of the …, 2023 - pnas.org
Molecular clocks in the periphery coordinate tissue-specific daily biorhythms by integrating
input from the hypothalamic master clock and intracellular metabolic signals. One such key …

The circadian clock and metabolic homeostasis: entangled networks

LVM de Assis, H Oster - Cellular and Molecular Life Sciences, 2021 - Springer
The circadian clock exerts an important role in systemic homeostasis as it acts a keeper of
time for the organism. The synchrony between the daily challenges imposed by the …

Time-restricted feeding attenuates hypercholesterolaemia and atherosclerosis development during circadian disturbance in APOE∗ 3-Leiden. CETP mice

WIH Panhuis, M Schönke, M Modder, HE Tom… - …, 2023 - thelancet.com
Background Circadian disturbance (CD) is the consequence of a mismatch between
endogenous circadian rhythms, behaviour, and/or environmental cycles, and frequently …

Mechanisms in endocrinology: local and systemic effects of glucocorticoids on metabolism: new lessons from animal models

M Swarbrick, H Zhou, M Seibel - European journal of …, 2021 - academic.oup.com
Glucocorticoids regulate a remarkable variety of essential functions, including development,
immunomodulation, maintenance of circadian rhythm and the response to stress …