Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease
Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …
dependent dementia. There is currently no effective treatment for AD, which may be …
Visualization of neurofibrillary tangle maturity in Alzheimer's disease: A clinicopathologic perspective for biomarker research
Neurofibrillary tangles, one of the neuropathologic hallmarks of Alzheimer's disease, have a
dynamic lifespan of maturity that associates with progressive neuronal dysfunction and …
dynamic lifespan of maturity that associates with progressive neuronal dysfunction and …
Oxidative stress occurs prior to amyloid Aβ plaque formation and tau phosphorylation in Alzheimer's disease: Role of glutathione and metal ions
Alzheimer's disease (AD) is an insidious and progressive neurodegenerative disorder that
affects millions of people worldwide. Although the pathogenesis remains obscure, there are …
affects millions of people worldwide. Although the pathogenesis remains obscure, there are …
Roles of tau protein in health and disease
Tau is well established as a microtubule-associated protein in neurons. However, under
pathological conditions, aberrant assembly of tau into insoluble aggregates is accompanied …
pathological conditions, aberrant assembly of tau into insoluble aggregates is accompanied …
Liquid-liquid phase separation induces pathogenic tau conformations in vitro
Formation of membrane-less organelles via liquid-liquid phase separation is one way cells
meet the biological requirement for spatiotemporal regulation of cellular components and …
meet the biological requirement for spatiotemporal regulation of cellular components and …
[HTML][HTML] MAPT mutations, tauopathy, and mechanisms of neurodegeneration
In multiple neurodegenerative diseases, including Alzheimer's disease (AD), a prominent
pathological feature is the aberrant aggregation and inclusion formation of the microtubule …
pathological feature is the aberrant aggregation and inclusion formation of the microtubule …
Mechanisms of secretion and spreading of pathological tau protein
CA Brunello, M Merezhko, RL Uronen… - Cellular and Molecular …, 2020 - Springer
Accumulation of misfolded and aggregated forms of tau protein in the brain is a
neuropathological hallmark of tauopathies, such as Alzheimer's disease and frontotemporal …
neuropathological hallmark of tauopathies, such as Alzheimer's disease and frontotemporal …
Role of the extracellular matrix in Alzheimer's disease
Y Sun, S Xu, M Jiang, X Liu, L Yang, Z Bai… - Frontiers in aging …, 2021 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disease with complex pathological
characteristics, whose etiology and pathogenesis are still unclear. Over the past few …
characteristics, whose etiology and pathogenesis are still unclear. Over the past few …
Tau proteolysis in the pathogenesis of tauopathies: neurotoxic fragments and novel biomarkers
JP Quinn, NJ Corbett, KAB Kellett… - Journal of Alzheimer's …, 2018 - content.iospress.com
With predictions showing that 131.5 million people worldwide will be living with dementia by
2050, an understanding of the molecular mechanisms underpinning disease is crucial in the …
2050, an understanding of the molecular mechanisms underpinning disease is crucial in the …
[HTML][HTML] The role of amyloid oligomers in neurodegenerative pathologies
Many neurodegenerative diseases are rooted in the activities of amyloid-like proteins which
possess conformations that spread to healthy proteins. These include Alzheimer's disease …
possess conformations that spread to healthy proteins. These include Alzheimer's disease …