The failure of animal models to predict therapeutic responses in humans is a major problem
that also brings into question their use for basic research. Organ-on-a-chip (organ chip) …

The gastrointestinal tract is involved in coronavirus disease 2019 (COVID-19) caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The gut microbiota has …

Both passive and active microfluidic chips are used in many biomedical and chemical
applications to support fluid mixing, particle manipulations, and signal detection. Passive …

In some patients, COVID-19 can trigger neurological symptoms with unclear pathogenesis.
Here we describe a microphysiological system integrating alveolus and blood–brain barrier …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global
pandemic. Antibody resistance dampens neutralizing antibody therapy and threatens …

The intestine is considered to be a vital digestive organ to absorb nutrients and is the largest
immune organ, while numerous microorganisms coexist with the host. It is well known that …

Drug evaluation has always been an important area of research in the pharmaceutical
industry. However, animal welfare protection and other shortcomings of traditional drug …

Organoids/organs-on-a-chip open up new frontiers for basic and clinical research of
intestinal diseases. Species-specific differences hinder research on animal models, while …

Genome-wide association studies (GWAS) have now correlated hundreds of genetic
variants with complex genetic diseases and drug efficacy. Functional characterization of …

The organ-on-a-chip (OoC) paves a way for biomedical applications ranging from preclinical
to clinical translational precision. The current trends in the in vitro modeling is to reduce the …