Infections in critically ill patients are associated with persistently poor clinical outcomes.
These patients have severely altered and variable antibiotic pharmacokinetics and are …

The emergence of carbapenem resistance in Enterobacteriaceae is an important threat to
global health. Reported outcomes of infections with carbapenem-resistant …

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Objective: To discuss the altered pharmacokinetic properties of selected antibiotics in
critically ill patients and to develop basic dose adjustment principles for this patient …

Despite the extensive study of tetracycline photolysis in aquatic environments, the
phototransformation of tetracycline and its metabolites under natural day-night succession …

The pharmacodynamics of an antimicrobial drug relates its pharmacokinetics to the time
course of the antimicrobial effects at the site of the infection. Knowledge of the drug's …

The pharmacokinetics of tetracyclines and glycylcyclines are described in three groups.
Group 1, the oldest group, represented by tetracycline, oxytetracycline, chlortetracycline …

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The emergence of multidrug-resistant (MDR) Gram-negative bacilli creates a challenge in
the treatment of nosocomial infections. While the pharmaceutical pipeline is waning, two …

Tetracyclines are a broad-spectrum class of antibiotics that have unclear actions with
potentially lasting effects on bone metabolism. Initially isolated from Streptomyces …