Following primary infection, human cytomegalovirus (HCMV) establishes lifelong latency
and periodically reactivates without causing symptoms in healthy individuals. In the absence …

Epstein-Barr virus (EBV) provides a useful model to study cellular immunity to a genetically
stable, persistent human virus. Different sets of proteins expressed during EBV's lytic and …

Summary SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune
protection against COVID-19. Here, we systematically mapped the functional and …

Emerging data indicate that SARS-CoV-2-specific CD8+ T cells targeting different viral
proteins are detectable in up to 70% of convalescent individuals,,,–. However, very little …

Immunological memory is thought to depend on a stem cell–like, self-renewing population of
lymphocytes capable of differentiating into effector cells in response to antigen re-exposure …

Adoptive transfer of tumor-infiltrating lymphocytes (TILs) can mediate regression of
metastatic melanoma; however, TILs are a heterogeneous population, and there are no …

T cell memory relies on the generation of antigen-specific progenitors with stem-like
properties. However, the identity of these progenitors has remained unclear, precluding a …

T cell immunity can potentially eradicate malignant cells and lead to clinical remission in a
minority of patients with cancer. In the majority of these individuals, however, there is a …

The ability to decode antigen specificities encapsulated in the sequences of rearranged T-
cell receptor (TCR) genes is critical for our understanding of the adaptive immune system …

An individual's T cell repertoire dynamically encodes their pathogen exposure history. To
determine whether pathogen exposure signatures can be identified by documenting public T …